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Informationen zum Autor Patricia Frank is President of Patricia Frank & Associates, Inc., a consulting firm founded in 1993 that assists companies in the development and registration of human and veterinary pharmaceutical agents. She is a past president of both the American College of Toxicology and the Roundtable of Toxicology Consultants. M. Alice Ottoboni lectures, writes, and consults in the field of toxicology. As Staff Toxicologist with the California State Department of Public Health for over twenty years, she originated, designed, and performed numerous toxicological studies of environmental factors of importance to public health. She is the author of the previous editions of The Dose Makes the Poison . Klappentext An introductory guide to the history, concepts, and practice of toxicologyWith the advent of serious industrialization in non-Western economies such as China and India, the integrity of our food supply is once again in question and the safety of various consumer products and medicines at risk. Every day, people are exposed to a wide array of chemicals and other potential toxicants--from industrial emissions, the natural environment, drugs, and consumer products. Using broadly accessible language and clear examples, the Third Edition of The Dose Makes the Poison updates its highly acclaimed predecessors and explains the basics and practice of toxicology in easy-to-understand language.This new edition broadens its scope from a heavy focus on industrial chemicals as toxicants to include drugs, food additives, cosmetics, and other types of compounds that people are exposed to daily. Also new to the Third Edition are recent issues-of-the-day such as bisphenol A, secondhand smoke, food contamination, lead in toys, melamine toxicity to children and pets, and drug recalls. Basic principles of how doses and routes of administration alter toxicity, testing paradigms for drugs and chemicals, and newer technology such as nanoparticles are all addressed and explained. In addition, the book:* Presents case studies of historical and current interest to illustrate various aspects of toxicology* Deals with all types of chemicals that we confront every day, including drugs, food additives, vitamins, and others* Includes an introduction to how chemicals cause harm, the factors that influence toxicity, and the ways that chemicals and drugs are tested to determine their safety Zusammenfassung This new edition of a widely-read and highly-acclaimed book broadens the scope of its predecessors from a heavy focus on industrial chemicals as toxicants to include drugs, food additives, cosmetics and other types of compounds that people are exposed to daily. Also new to the 3rd edition are newer issues-of-the-day such as nanoparticulate toxicants, second hand smoke, food contamination, lead in toys, and others. As such, the book provides the basics of toxicology in easy-to-understand language as well as a fuller understanding of the daily insults to which our bodies are subjected. Inhaltsverzeichnis Introduction to the Third Edition xi Preface to the Second Edition xv 1 What Are Chemicals? 1 Atoms and Molecules 1 Natural Chemicals 2 Synthetic Chemicals 3 Chemical Categories 6 Chemicals: "Good" and "Bad" 8 Why the "Good-Bad" Dichotomy? 10 Man-made Chemicals Are Made by Humans 11 Man-made Chemicals May Not Be Biodegradable 12 Man-made Chemicals May Be Very Complex 16 2 What Harm Do Chemicals Cause? 19 Harmful Properties of Chemicals 19 Explosiveness and Reactivity 19 Flammability and Combustibility 20 Radioactivity 21 Corrosiveness 23 Irritation 23 Sensitization and Photosensitization 24 Toxicity 26 Multiple Harmful Properties 27 Definition of Poison 28 Definition of Hazard 28 3 Wha...
