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Zusatztext "Tompa's masterly compendium on intrinsically disordered proteins arrives at just the right time to fill a conspicuous void on this important topic. His eminently readable book is broad enough to educate beginners but deep enough to inform experts."—George Rose, Ph.D., Johns Hopkins University, Baltimore, Maryland, USA"Peter Tompa’s fine comprehensive overview of this rapidly advancing field is of timely importance, both for its documentation and for emphasizing the importance of IDPs in biology and protein science. … This book demonstrates Tompa’s considerable command of the field, providing appropriate examples and ample details in every respect. Its coverage of the latest developments in the field is impressive, and the author manages to strike a good balance between detail and concept to lead the reader through this novel field."—From the Foreword by Professor Sir Alan Fersht, University of Cambridge, UK"The book is just superb—a thorough, comprehensive and lucid discussion of intrinsically disordered proteins."—Joel L. Sussman, Weizmann Institute of Science, Rehovot, Israel Informationen zum Autor Peter Tompa is Group Leader in the Laboratory of Intrinsically Disordered Proteins, Institute of Enzymology, Biological Research Center at the Hungarian Academy of Sciences in Budapest. Klappentext A detailed investigation into intrinsically disordered proteins (IDP), this seminal work illustrates how IDPs defy the structure-function paradigm and play important regulatory and signaling roles. Introducing basic terms and fundamental principals of protein science, the author presents a unified theory of ordered and disordered proteins and outlines new applications for traditional biophysical and bioinformatic techniques, such as x-ray crystallography and NMR. The book reviews the structure, function, and evolution of IDPs and considers biomedical implications as well as applications in drug development for cancer and neurodegenerative diseases. "Tompa's masterly compendium on intrinsically disordered proteins arrives at just the right time to fill a conspicuous void on this important topic. His eminently readable book is broad enough to educate beginners but deep enough to inform experts." -George Rose, Ph.D., Johns Hopkins University, Baltimore, Maryland, USA "Peter Tompa's fine comprehensive overview of this rapidly advancing field is of timely importance, both for its documentation and for emphasizing the importance of IDPs in biology and protein science. ... This book demonstrates Tompa's considerable command of the field, providing appropriate examples and ample details in every respect. Its coverage of the latest developments in the field is impressive, and the author manages to strike a good balance between detail and concept to lead the reader through this novel field." -From the Foreword by Professor Sir Alan Fersht, University of Cambridge, UK "The book is just superb-a thorough, comprehensive and lucid discussion of intrinsically disordered proteins." -Joel L. Sussman, Weizmann Institute of Science, Rehovot, Israel Zusammenfassung Providing the treatment of the field of protein disorder, this book illustrates how IDPs defy the structure-function paradigm and play important regulatory and signaling roles. It introduces basic terms and fundamental principles of protein science and presents a unified theory of ordered and disordered proteins. Inhaltsverzeichnis Principles of Protein Structure and Function. A Brief History of Protein Disorder. Indirect Techniques for Recognizing and Characterizing Protein Disorder. Hydrodynamic Techniques. Spectroscopic Techniques for Characterizing Disorder. Nuclear Magnetic Resonance. Proteomic Approaches for the Identification of IDPs. IDPs under Conditions Approaching In Vivo . Prediction of Disorder. Structure of IDPs. Biological Processes Enriched in Disorder. Molecular F...
