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Zusatztext The information presented in this book is definitely of value to any laboratory engaged in toxicology analysis and the quantification of drugs.-Maria Reid! Royal Canadian Mounted Police! Canadian Society of Forensic Science! Vol. 43! No. 1! March 2010The book is of obvious utility to those analysts who work indrug analysis and to those who are confronted occasionally witha drug-analysis problem. The strategies outlined in this work areimportant to anyone who is conducting trace analysis bychromatography coupled with mass spectrometry.-Michael L. Gross! Journal of the American Society for Mass Spectrometry Informationen zum Autor Ray H. Liu is a professor in the Department of Medical Technology at Fooyin University in Taiwan and professor emeritus in the Department of Justice Sciences at the University of Alabama in Birmingham. Sheng-Meng Wang is a professor of forensic science and director of scientific laboratories at Central Police University in Taiwan. Dennis V. Canfield is the manager of the Bioaeronautical Sciences Research Laboratory at the U.S. Federal Aviation Administration’s Civil Aerospace Medical Institute (CAMI) in Oklahoma City, Oklahoma. Zusammenfassung A reference for labs involved in the analysis of abused and therapeutic drugs that features more than 1500 full-scan mass spectra data tables. It illustrates approaches, mechanisms, and challenges pertaining to the use of isotopic analogs as internal standards for drug quantitation. Inhaltsverzeichnis Part One. Isotopically Labeled Analog as Internal Standard for Drug Quantitation - MethodologyQuantitation of Drug in Biological Specimen - Isotopically Labeled Analog of the Analyte as Internal Standard IntroductionSignificance of Accurate QuantitationPreferred Calibration MethodInternal Standard and Quantitation IonsInadequate Isotopic Purity - An Extrinsic FactorCross-Contribution Derived from Ion Fragmentation Mechanism - An Intrinsic FactorFitting Calibration Data2H- Versus 13C-Analogs as Internal StandardsConcluding RemarksReferencesIsotopically Labeled Analog of the Analyte as Internal Standard for Drug Quantitation - Chemical Derivatization and Data Collection and Evaluation IntroductionChemical DerivatizationProduction of Most Favorable Ion-Pairs for Drug QuantitationExemplar StudiesIsotopically Labeled Analogs and Chemical Derivatization GroupsIon Intensity Cross-Contribution Data Full-Scan Mass SpectraSelected Ion Monitoring and Calculation of Cross-Contribution Data:Direct Measurement! Normalized Direct Measurement! Internal Standard Method! Standard Addition MethodAssessing the Accuracy of Empirically Determined Cross-Contribution Data:Experimentally Observed Concentration! Theoretically Calculated Concentration! Comparing Empirically Derived and Theoretically Calculated Concentrations - Graphic Presentation! SummaryCompilation of Full-Scan Mass Spectra and Ion Intensity Cross-Contribution Tables:Derivatization Procedures! Instrumentation! and Analytical Parameters Collection of Mass Spectrometric DataIon Intensity Cross-Contribution DataConcluding RemarksReferencesPart Two. Mass Spectra of Commonly Abused Drugs and Their Isotopically Labelled Analogs in Various Derivatization FormsTable of Contents for Appendix OneStimulantsOpioidsHallucinogensDepressants/HypnoticsAntianxiety AgentsAntidepressantsOthersPart Three. Cross-Contributions of Ion Intensity Between Analytes and Their Isotopically Labeled Analogs in Various Derivatization FormsTable of Contents for Appendix TwoStimulantsOpioidsHallucinogensDepressants/HypnoticsAntianxiety AgentsAntidepressantsOthersIndex ...
