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Informationen zum Autor Gustavo Stolovitzky is the editor of The Challenges of Systems Biology: Community Efforts to Harness Biological Complexity, Volume 1158, published by Wiley. Pascal Kahlem is the editor of The Challenges of Systems Biology: Community Efforts to Harness Biological Complexity, Volume 1158, published by Wiley. Klappentext At a microscopic level, organisms are ruled by interacting systems of biomolecules. Historically, scientists painstakingly elucidated chains of molecular events using experiments that reveal individual interactions, although they recognized that members of different pathways frequently interact. In recent years, researchers have built richer, interconnected networks to mathematically summarize their knowledge of these interactions. This systems biology enterprise, largely stimulated by high-throughput tools like microarrays that measure mRNA levels as an indicator of gene expression, is a vital and increasingly important activity in both basic biology and in medicine. A nagging concern, however, is how accurately these networks represent the biology. For complex systems like biological networks, there are practical limits on how well even massive amounts of data can uniquely define the underlying structure and yield useful predictions of measurable events. Indeed, although its advocates call this process "reverse engineering," the topology and the detailed molecular interactions of the "inferred" networks will likely never be known with precision. This volume captures the ongoing process to assess the ability of scientists--and their computer servants--to infer networks from experimental data, by comparing their predictions to "gold-standard" networks whose structure is thought to be known. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas . ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order ( www.nyas.org ). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member. Zusammenfassung At a microscopic level! organisms are ruled by interacting systems of biomolecules. Historically! scientists painstakingly elucidated chains of molecular events using experiments that reveal individual interactions! although they recognized that members of different pathways frequently interact. Inhaltsverzeichnis Preface: Gustavo Stolovitzky, Pascal Kahlem, and Andrea Califano Part I: Selected Papers from the ENFIN-DREAM Joint Conference 1. Ranking genes by their co-expression to subsets of pathway members: Priit Adler, Hedi Peterson, Phaedra Agius, Jüri Reimand, and Jaak Vilo 2. Creating reference datasets for Systems Biology applications using text mining: Martin Krallinger, Ana Maria Rojas, and Alfonso Valencia Selected Papers from the DREAM2 Conference Transcriptional Modules and Regulatory Networks 3. Condition-dependent combinatorial regulation in Escherichia coli: Karen Lemmens, Tijl De Bie, Thomas Dhollander, Pieter Monsieurs, Bart De Moor, Julio Collado-Vides, Kristof Engelen, and Kathleen Marchal 4. Reverse-engineering transcriptional modules from gene expression data: Tom Michoel, Riet De Smet , Anagha Joshi, Kathleen Marchal and Yves Van de Peer Signaling and Metabolic Networks 5. Specification of spatial relationships in directed graphs of cell signaling networks: Azi Lipshtat, Susana R. Neves, and Ravi Iyengar 6. Uncovering metabolic objectives pursued by changes of enzyme levels: Sabrina Hoffmann and Hermann-Georg Holzhütter. Biological Network Models 7. Modeling of Gene Regula...
