Artificial Receptors for Chemical Sensors

The selective binding of a particular compound to another is a lockand-key principle omnipresent in living organisms and an indispensable
means of information transport and triggering responses. Derived from the biological archetype, synthetic receptors imitate nature`s idea
for tailor-made functionalities such as detection (sensing), signaling, and triggering. This book provides systematically organized information
on all three important aspects of artifi cial receptor design as well as the knowledge on an exceptionally hot and multidisciplinary field of
research. Strong emphasis is placed on the methodology for discovering artificial receptors, with both defi nitions for chemosensitivity as
well as experimental setups supplied. Numerous classes of artificial receptors are covered, as well as their synthesis, immobilization on
surfaces, and quantitative data on their properties. The fi nal chapter with all relevant quantitative data on artifi cial receptors complete this
well-rounded book.

List of contents

PrefaceQUANTITATIVE CHARACTERIZATION OF AFFINITY PROPERTIES OF IMMOBILIZED RECEPTORSIntroductionMeasurements Under Equilibrium ConditionsKinetic MeasurementsAnalysis of Temperature DependenciesExperimental TechniquesSELECTIVITY OF CHEMICAL RECEPTORSIntroductionSome General Considerations on SelectivityCorrelation Between Selectivity and AffinityCrown Ether and Cryptand Complexes: Hole Size Fitting and Other EffectsRecogniction of Transition and Heavy Metal IonsRecognition via Ion PairingHydrogen Bonded Complexes and Solvent EffectsLewis Acid ReceptorsComplexes with Stacking and van der Waals InteractionsMultifunctional Receptors for Recognition of Complex Target MoleculesConclusionsCOMBINATORIAL DEVELOPMENT OF SENSING MATERIALSIntroductionGeneral Principles of Combinatorial Materials ScreeningOpportunities for Sensing MaterialsDesigns of Combinatorial Libraries of Sensing MaterialsDiscovery and Optimization of Sensing Materials Using Discrete ArraysOptimization of Sensing Materials Using Gradient ArraysEmerging Wireless Technologies for Combinatorial Screening of Sensing MaterialsSummary and OutlookFLUORESCENT CYCLODEXTRINS AS CHEMOSENSORS FOR MOLECULE DETECTION IN WATERIntroductionPyrene-Appended CyclodextrinsFluorophore-Amino Acid-CD Triad SystemsMolecular Recognition by Regioisomers of Dansyl-Appended CDsTurn-On Fluorescent ChemosensorsEffect of Protein Environment on Molecule SensingCD-Peptide Conjugates as ChemosensorsImmobilized Fluorescent CD on a Cellulose MembraneConclusionCYCLOPEPTIDE DERIVED SYNTHETIC RECEPTORSIntroductionReceptors for CationsReceptors for Ion PairsReceptors for AnionsReceptors for Neutral SubstratesConclusionBONORIC ACID-BASED RECEPTORS AND CHEMOSENSORSIntroductionDe Novo DesignCombinatorial ApproachesTemplate Directed SynthesisARTIFICIAL RECEPTOR COMPOUNDS FOR CHIRAL RECOGNITIONIntroductionCyclodextrinsCrown EthersCalixarenesCalix[4]resorcinarenesMiscellaneous Receptor CompoundsMetal-Containing Receptor CompoundsFULLERENE RECEPTORS BASED ON CALIXARENE DERIVATIVESIntroductionCalixarenesSolid State Complexation by CalixarenesComlexation in SolutionCalixarenes as Molecular ScaffoldsOutlookGUANIDINIUM BASED ANION RECEPTORSIntroductionInstructive Historical ExamplesRecent Advances in Inorganic Anion RecognitionOrganic and Biological PhosphatesPolycarboxylate BindingAmino Acid RecognitionDipeptides as SubstratePolypeptide RecognitionConclusionARTIFICIAL RECEPTORS BASED ON SPREADER-BAR SYSTEMSPOTENTIAL OF APTAMERS AS ARTIFICIAL RECEPTORS IN CHEMICAL SENSORSIntroductionGeneration and Synthesis of AptamersAptamer ArraysTechniques for Readout of Ligand Binding to the AptamerOutlook/SummaryCONDUCTING POLYMERS AS ARTIFICIAL RECEPTORS IN CHEMICAL SENSORSIntroductionTransducers for Artificial Receptors Based on Conducting PolymersIntrinsic Sensitivity of Conducting PolymersConducting Polymers Modified with Receptor GroupsConclusionMOLECULARLY IMPRINTED POLYMERS AS ARTIFICIAL RECEPTORSIntroductionFundamentals of Molecular ImprintingPolymer Formats and Polymerization Methods for MIPsEvaluation of MIP Performance - Imprinting EfficiencyMIPs Mimicking Natural ReceptorsConclusions and OutlookQUANTITATIVE AFFINITY DATA ON SELECTED ARTIFICIAL RECEPTORSStructures of Receptors

About the author

Vladimir M. Mirsky is Professor at Regensburg University, Germany. He graduated from Moscow Medical University in 1981 as M.D. in biophysics and went on to study physical chemistry and electrochemistry at the Frumkin Institute of Electrochemistry of the Soviet Academy of Sciences, obtaining his Ph.D. in 1986. He subsequently held an Alexander-von-Humboldt Research Fellowship and a research position at the CNRS Centre of Molecular Biology in France prior to joining the Institute of Analytical Chemistry at Regensburg University in 1995. He editor of two recent books, "Ultrathin Electrochemical Chemo- and Biosensors" and "Combinatorial Methodologies for Development of Chemical and Biological Sensors". His work has led to 18 patents and patent applications as well as some 100 peer-reviewed scientific papers.

Anatoly K. Yatsimirsky is Professor of chemistry at the National Autonomous University of Mexico in Mexico City. He obtained his Ph.D. and Dr. Sc. degrees from Moscow Lomonosov State University, where he was Professor prior to his move to Mexico in 1992.
He spent Visiting Scholar/Professor stays at Milan University, Italy, in 1980/81 and at the University of California at Santa Barbara in 1998/99. His research is focused on physical organic chemistry and metal complex catalysis and he is the author of 160 peer-reviewed scientific publications including a monograph "Principles and Methods in Supramolecular Chemistry" by John Wiley & Sons and further book contributions.

Summary

The first to provide systematically organized information on all three important aspects of artificial receptor design, this book brings together knowledge on an exceptionally hot and multidisciplinary field of research. Strong emphasis is placed on the methodology for discovering artificial receptors, with both definitions for chemosensitivity as well as experimental setups supplied. There follows coverage of numerous classes of artificial receptors, including synthesis, immobilization on surfaces, and quantitative data on properties. The third part of the book focuses on receptor arrays for artificial nose and tongue applications and the whole is rounded off with an outlook and an appendix with all relevant quantitative data on artificial receptors.

Report

"Artificial Receptors for Chemical Sensors provides a well-rounded summary of applications of
macromolecular receptors in the field of chemical sensors without neglecting the fundamentals of sensor design and function. The chapters are well-written and nicely balance the basic chemistry and practical applications of artificial receptors. The book will be a valuable resource for scientists working on all aspects of sensor development from the initial design to bringing sensors to the market." (Analytical and Bioanalytical Chemistry, 2011)

Product details

• Authors: Vladimir M. Mirsky, Anatoly Yatsimirsky
• Assisted by: Vladimi M Mirsky (Editor), Vladimir M Mirsky (Editor), Vladimir M. Mirsky (Editor), Yatsimirsky (Editor), Yatsimirsky (Editor), Anatoly Yatsimirsky (Editor)
• Publisher: Wiley-VCH
• Languages: English
• Product format: Hardback
• Released: 22.12.2010
• EAN: 9783527323579
• ISBN: 978-3-527-32357-9
• No. of pages: 470
• Dimensions: 178 mm x 246 mm x 28 mm
• Weight: 1062 g
• Illustrations: 169 SW-Abb., 33 Farbabb.
• Subjects: Natural sciences, medicine, IT, technology > Biology > Miscellaneous; Chemie, Physik, Sensor, Nanotechnologie, Physikalische Chemie, Sensoren, Festkörperphysik, chemistry, Physics, Materialwissenschaften, Rezeptor, Solid State Physics, Nanotechnology, Materials science, Physical Chemistry, Nanobiotechnologie, Nanobiotechnology, Sensor Materials