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Edited by a top expert, this book represents a powerful tool showing how to successfully apply ESI-MS in revealing, elucidating and helping to consolidate several proposed mechanisms of organic reactions that need to be emphasized.With a foreword by Chris Enke
List of contents
PrefaceA BRIEF OVERVIEW OF THE MECHANISMS INVOLVED IN ELECTROSPRAY MASS SPECTROMETRYIntroductionProduction of Gas-Phase Ions by Electrospray and Electrospray Ionization Mass SpectrometryHISTORICAL PERSPECTIVES IN THE STUDY OF ION CHEMISTRY BY MASS SPECTROMETRY: FROM THE GAS PHASE TO SOLUTIONA Brief History and Recent Advances in Mass SpectrometryOverview of the Study of Ion/Molecule Reactions in the Gas Phase by Mass SpectrometryFuture PerspectivesORGANIC REACTION STUDIES BY ESI-MSIntroductionReaction MechanismsGeneral RemarksSTUDIES OF REACTION MECHANISM INTERMEDIATES BY ESI-MSIntroductionStudies on the Intermediates and Mechanisms of Pd-Catalyzed ReactionsStudies on Some Reactive Intermediates and Mechanisms of Radical ReactionsStudies on the Intermediates and Mechanism of Organocatalysis ReactionsStudies on the Intermediates and Mechanism of Transition Metal-Catalyzed Polymerization ReactionsON-LINE MONITORING REACTIONS BY ELECTROSPRAY IONIZATION MASS SPECTROMETRYIntroductionPreservation of the Charge in the Transit of Ions from Solution to the Gas Phase Using the ESI TechniqueDeveloping Methods to Study Reaction MechanismsProbing Reactivity of IntermediatesConclusionGAS PHASE LIGAND FRAGMENTATION TO UNMASK REACTIVE METALLIC SPECIESIntroduction and Scope of the ReviewUnmasking Reactive Metallic Intermediates via Collision-Induced DissociationConclusionsPALLADIUM INTERMEDIATES IN SOLUTIONIntroductionESI-MS Studies in Suzuki-Miyaura Cross-Coupling and Related ReactionsESI-MS Studies in the Identification of Oxidative Addition IntermediatesESI-MS Studies in Mizoroki-Heck and Related ReactionsESI-MS Studies in Stille Cross-Coupling ReactionsESI-MS Studies in Palladium-Catalyzed Reactions Involving AllenesESI-MS Studies in Palladium-Catalyzed Alkynylation ReactionsESI-MS Studies in Palladium-Catalyzed Allylic Substitution ReactionsESI-MS Studies in Palladium-Catalyzed Oxidation of 2-AllylphenolsESI-MS Studies in Palladium-Catalyzed Polymerization ReactionsConclusionsPRACTICAL INVESTIGATION OF MOLECULAR AND BIOMOLECULAR NONCOVALENT RECOGNITION PROCESSES IN SOLUTION BY ESI-MSIntroductionMethods and ApplicationsPractical Aspects of Titration AnalysisSummary and Outlook
About the author
After being awarded his MSc in 1999 Leonardo Silva Santos joined the Universidade Estadual de Campinas in Brasil for his thesis working on the total synthesis of natural products, while also doing research for two years at the University of Chicago in 2001-2002. After beind awarded his Ph.D. in 2003 he did postdoctoral research at UNICAMP, Brasil, and at the Carl von Ossietzky Universität Oldenburg. He is currently Professor at the Universidad de Talca, Chile.
Summary
Edited by a top expert, this book represents a powerful tool showing how to successfully apply ESI-MS in revealing, elucidating and helping to consolidate several proposed mechanisms of organic reactions that need to be emphasized.
With a foreword by Chris Enke
Report
"In summary, this is a good source for researchers looking to utilize mass spectrometry for detecting reactive species in organic and organometallic reactions or for studying their mechanisms. It would be a worthwhile acquisition for libraries and individual scientists alike." (Journal of the American Chemical Society, November 2010)
