Read more
Informationen zum Autor Ahcéne Boumendjel is Professor of Medicinal Chemistry at the University of Grenoble School of Pharmacy, France. Jean Boutonnat is an Assistant Professor and Hospital Practitioner at the Grenoble Medical School and Université Joseph Fourier of Grenoble, France. Jacques Robert is Professor and Head of the Laboratory of Pharmacology of Anticancer Agents at Institut Bergonié and Université Victor Segalen Bordeaux 2, France. Klappentext Wiley Series in Drug Discovery and DevelopmentBinghe Wang, Series EditorABC Transporters and Multidrug ResistanceEdited byAhcène BoumendjelJean BoutonnatJacques RobertA comprehensive review of the most current scientific research on ABC transporters and multidrug resistanceATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs.ABC Transporters and Multidrug Resistance offers an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance.This comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance. Zusammenfassung This book gathers present knowledge on the involvement of ABC transporters in drug transport and resistance. Bringing together updated information from an otherwise-scattered field of scientific literature, this resource helps researchers in pharmaceutical science in discovering drugs able to counteract multidrug resistance in diseases like cancer. Inhaltsverzeichnis PREFACE ix CONTRIBUTORS xi INTRODUCTION: WHAT IS MULTIDRUG RESISTANCE? 1 Jonathan A. Sheps and Victor Ling PART I ABC PROTEINS: AN OVERVIEW AND DESCRIPTION OF THE STRUCTURE, GENOME, NORMAL TISSUE EXPRESSION, PHYSIOLOGICAL ASPECT, AND MECHANISM OF ACTION 15 1 The P-glycoprotein 170: Just a multidrug resistance protein or a protean molecule? 17 Fabienne Grandjean-Forestier, Christophe Stenger, Jacques Robert, Mireille Verdier, and Marie-Hélène Ratinaud 2 Multidrug resistance-associated protein (MRP/ABCC proteins) 47 Mylène Honorat, Charles Dumontet, and Lea Payen 3 ABCG2: A new challenge in cancer drug resistance 83 Orsolya Polgar, Robert W. Robey, Kin Wah To, John Deeken, Patricia A. Fetsch, and Susan E. Bates PART II ABC PROTEINS AND ONCOLOGY: EXPRESSION, DETECTION, AND IMPLICATION OF ABC PROTEINS IN HEMATOLOGICAL MALIGNANCIES AND SOLID TUMORS 119 4 Expression, detection, and implication of ABC proteins in acute myeloblastic leukemia 121 Ollivier Legrand, Ruo-Ping Tang, and Jean-Pierre Marie 5 ABC proteins and oncology: Expression, detection, and implication of ABC proteins in solid tumors 143 Jean François Bernaudin, Anne Fajac, Jocelyne Fleury-Feith, Khaldoun Kerrou, and Roger Lacave PART III ABC PROTEINS AND PAT...
