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Informationen zum Autor Zhongwu Guo is a Professor of Chemistry at Wayne State University. The winner of the American Chemical Society's 2005 New Investigator Award in Carbohydrate Chemistry, Dr. Guo serves on the editorial board of the Journal of Carbohydrate Chemistry, speaks regularly at international conferences, and has authored more than ninety peer-reviewed publications. Geert-Jan Boons is a Franklin Professor of Chemistry at the Complex Carbohydrate Research Center (CRCR) of the University of Georgia. The winner of the European Carbohydrate Association's Carbohydrate Research Award for Creativity in Carbohydrate Science, and the American Chemical Society's Horace Isbell Award, Dr. Boons serves on the editorial boards of Journal of Carbohydrate Chemistry and Advances in Carbohydrate Chemistry and Biochemistry. Klappentext The fundamental science and the latest developments in carbohydrate-based vaccinesThe relatively new field of glycoimmunology has emerged from the marriage of glycobiology and immunology, in recognition of the important role carbohydrates play as antigenic determinants. Carbohydrate-Based Vaccines and Immunotherapies comprehensively reviews the state of this exciting field, offering a single source for both the fundamental science and the latest developments.With contributions by leading experts, this resource covers the design, synthesis, evaluation, and applications of various carbohydrate-based vaccines, including polysaccharides, neoglycoproteins, and neoglycolipids. The text approaches vaccine design from a chemical and molecular focus, staying in line with current advances.Key topics covered by Carbohydrate-Based Vaccines and Immunotherapies include:* Recent developments towards clinically useful vaccines against bacteria, viruses, parasites, and fungi* Using adjuvants to improve immunogenicity and/or immunological properties of vaccines* Choosing and designing proper adjuvants for specific targets* Abnormal carbohydrates expressed by tumors* Carbohydrate-based therapeutic cancer vaccines or cancer immunotherapy* Clinical trials results for synthetic cancer vaccines* Glycoengineering of cell surface carborhydrates and its anticancer applications* Using cell surface carbohydrates for disease diagnosisA single, convenient source of state-of-the-art information from leading authorities in the field, Carbohydrate-Based Vaccines and Immunotherapies is an essential reference for organic chemists and biochemists, academic researchers, and other students and professionals involved in vaccine design. Zusammenfassung Studies of vaccines derived from carbohydrate antigens have seen great progress. Synthetic carbohydrate-based vaccines, including polysaccharides, neoglycoproteins, and neoglycolipids, have been explored or used to prevent and treat bacterial and viral infections, cancer, and other diseases. Inhaltsverzeichnis Preface xv Contributors xvii 1 Glycobiology and Immunology 1 Udayanath Aich and Kevin J. Yarema 1.1 Introduction 1 1.2 Glycobiology 3 1.2.1 Glycosylation-Is It Worth the Cost? 3 1.2.2 Glycan Biosynthesis-A Dauntingly Complex Process 6 1.2.3 Glycoproteins 7 1.2.4 Lipid-Based Glycans 16 1.2.5 Polysaccharides: Glycosaminoglycans and Bacterial Capsular Components 18 1.3 The Immune System 20 1.3.1 Introductory Comments 20 1.3.2 Overview of the Immune System 20 1.3.3 Glycoimmunobiology 23 1.3.4 Interplay between Glycosylation and Sugars: a Two-Way Street 27 1.4 Carbohydrate Antigens 28 1.4.1 Carbohydrate Antigens in Humans 28 1.4.2 Carbohydrates and Pathogens 30 1.4.3 Carbohydrate-Based Vaccines 34 1.4.4 Concluding Comments: Building on Success 38 Acknowledgment 38 References 38 2 Preparation of Glycoconjugate Vaccines 55 Wei Zou an...
