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Advances in genetics are transforming estimates of an individual's risk of developing cancer and approaches to prevention and management of cancer in those who may have increased susceptibility. Identifying and caring for patients with hereditary cancer syndromes and their family members present a complex clinical, scientific and social challenge. This textbook, by leading experts at Massachusetts General Hospital Cancer Center, highlights the current understanding of the genetics of hereditary cancers of the breast, ovary, colorectum, stomach, pancreas, kidney, skin, and endocrine organs. Practical guidelines for the use of genetic testing, cancer screening and surveillance, prophylactic surgery, and promising targeted therapeutic agents are discussed.
In addition, ongoing research involving genome-wide screens to identify novel modest risk-associated genetic loci are explored, along with new approaches to the application of genetic markers in guiding therapeutic options.
Summary
Advances in genetics are transforming estimates of an individual’s risk of developing cancer and approaches to prevention and management of cancer in those who may have increased susceptibility. Identifying and caring for patients with hereditary cancer syndromes and their family members present a complex clinical, scientific and social challenge. This textbook, by leading experts at Massachusetts General Hospital Cancer Center, highlights the current understanding of the genetics of hereditary cancers of the breast, ovary, colorectum, stomach, pancreas, kidney, skin, and endocrine organs. Practical guidelines for the use of genetic testing, cancer screening and surveillance, prophylactic surgery, and promising targeted therapeutic agents are discussed.
In addition, ongoing research involving genome-wide screens to identify novel modest risk-associated genetic loci are explored, along with new approaches to the application of genetic markers in guiding therapeutic options.
Additional text
From the reviews:
“This thorough book outlines the most common genetic contributions to cancer and reviews cancer genetics and genetic counseling as well as recent advances in genome-wide association studies (GWAS) research and personalized medicine. … a largely useful resource, particularly for students, residents, and entry-level clinicians in clinical cancer genetics.” (Heather H. Wetzel, Doody’s Review Service, August, 2010)
Report
From the reviews:
"This thorough book outlines the most common genetic contributions to cancer and reviews cancer genetics and genetic counseling as well as recent advances in genome-wide association studies (GWAS) research and personalized medicine. ... a largely useful resource, particularly for students, residents, and entry-level clinicians in clinical cancer genetics." (Heather H. Wetzel, Doody's Review Service, August, 2010)
