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Informationen zum Autor Imran Ali , PhD, is Associate Professor at the Department of Chemistry, Jamia Millia Islamia (Central University), New Delhi, India. Dr. Ali has published more than 150 scholarly works, including complete books, book and encyclopedia chapters, review articles, research papers, technical reports, and conference presentations. Hassan Y. Aboul-Enein , PhD, is a Professor at Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo, Egypt. He has published more than 600 articles, including several books and encyclopedia chapters. Vinod K. Gupta is a Professor in the Department of Chemistry, Indian Institute of Technology, Roorkee, India. He has published more than 200 articles including book and encyclopedia chapters, review articles, research papers, technical reports, and conference presentations. Klappentext The latest tested and proven methods for detecting nanolevels of drugs and xenobioticsFilling an important gap in the literature, this book enables you to successfully perform nanoanalyses using chip-based nanoliquid chromatography (NLC) and nanocapillary electrophoresis (NCE). The authors carefully guide readers through each stage of the instrumentation, detection, and applications of NLC and NCE in order to accurately identify compounds at a nanogram per liter or lower. This is the first book in the world describing NLC and NCE techniques in separation science.Nanochromatography and Nanocapillary Electrophoresis begins with an introductory chapter that defines and sets forth a protocol for nanoanalyses. The chapters that follow guide you step by step through such important topics as:* Fabrication of microchips* Instrumentation, detection, and sample preparation in NLC and NCE* Nano high-performance liquid chromatography* Nanocapillary electrochromatography and nanomicellar electrokinetic chromatography* Chiral separations by nanoliquid chromatography and nanocapillary electrophoresisThroughout the book, the authors translate theory into practice, with examples of applications in materials science, nutrition, agriculture, chemistry, biology, and environmental science. Each chapter ends with a set of conclusions highlighting the most salient points as well as references to guide readers to the primary literature for further research.This book equips readers with new, sophisticated tools to detect and analyze drugs and xenobiotics at nano levels. It is therefore highly recommended for scientists, researchers, academicians, and students in analytical chemistry, environmental monitoring, drugs analyses, and chromatography. Zusammenfassung Details the instrumentation and application of nano chromatography and capillary electrophoresis in the detection of low level drug concentration. Offers practical explanations of all stages of nano sample detection. Discusses sample preparation methods. Inhaltsverzeichnis PREFACE xiii ACKNOWLEDGMENTS xv 1 Introduction 1 1.1. Nanoanalyses 1 1.2. Definition of Nanochromatography and Nanocapillary Electrophoresis 2 1.3. Nanochromatography and Nanocapillary Electrophoresis 3 1.4. Fabrication of Microdevices 4 1.5. Developments in Nanoanalyses 6 1.6. Data Integration 7 1.7. Protocol of Nanoanalyses 10 1.8. Scope of the Book 12 1.9. Conclusion 12 2 Fabrication of Microchips 17 2.1. Introduction 17 2.2. Substrates 18 2.3. Techniques of Fabrication 20 2.4. Surface Modification 39 2.5. Designs of Chips 45 2.6. Bindings in Chips 49 2.7. Conclusion 50 3 Instrumentation of Nanochromatography and Nanocapillary Electrophoresis 59 3.1. Introduction 59 3.2. Nanoliquid Chromatography (NLC) 60 3.3. Nanocapillary Electrophoresis ...
