Ultrastructural Pathology 2e - The Comparative Cellular Basis of Disease

Informationen zum Autor Norman F. Cheville, DVM, PhD, is Professor Emeritus of Veterinary Pathology at Iowa State University. Previously, he was Chair of the Department of Veterinary Pathology and Dean of the College of Veterinary Medicine at Iowa State University, and was Chief of Pathology at the National Animal Disease Center in Ames, Iowa. Klappentext Ultrastructural Pathology, Second Edition is a comprehensive reference on electron microscopy of pathologic tissue in animals and humans. Now presented in an atlas format for easier identification of organelles, the text is designed to bridge the gap between what is seen in the electron microscope at the cellular level and what the pathologist encounters in the postmortem room. New to this edition are sections on diagnostic electron microscopy, providing information on specialized technologies for electron microscopy, and invertebrate pathology. Emphasizing comparative pathology, the book explains and integrates all aspects of cellular changes in lesions occurring from natural or experimental disease. Zusammenfassung Ultrastructural Pathology, Second Edition is a comprehensive reference on electron microscopy of pathologic tissue in animals and humans. The text bridges the gap between what is seen in the electron microscope at the cellular level with what the pathologist encounters in the postmortem room. Inhaltsverzeichnis Preface xi Contributors xiii Prologue xv Part I: Structural Basis of Cell Injury 3 1 Response to Cellular Injury  5 Acute Cell Swelling 5 Adaptive Responses to Persistent Injury 21 2 Cell Death 33 Necrosis 35 Programmed Cell Death 40 Interplay of Necrosis and PCD 49 Getting Rid of the Dead Cell 52 Endothelial Cell Death 54 3 Cellular Defense and Recovery 61 Plasma Membrane in Recovery 61 Detoxification: Smooth Endoplasmic Reticulum and Peroxisomes 62 Mitochondria in Recovery 63 Nucleoli, DNA, and the Genome in Recovery 64 Proteostasis 67 Autophagy: Removal of Debris 69 Part II: Organelle Pathology 75 4 The Cell Surface 77 The Plasma Membrane 77 Cytoskeleton 86 Intercellular Junctions 97 Surface Structures 101 5 Intracellular Trafficking 109 Endocytosis 109 Phagocytosis 115 Lysosomes and Cytoplasmic Trafficking 116 Exocytosis 118 6 Nucleus, Ribosomes, the Golgi Complex, and Secretion 125 Nucleus 125 Ribosomes 136 Rough Endoplasmic Reticulum 138 Golgi Complex 139 Secretion 142 7 Peroxisomes, Smooth Endoplasmic Reticulum, and Lipids 153 Peroxisomes 153 Smooth Endoplasmic Reticulum 156 Glycogen 161 Lipids 164 Lipoproteins 169 Lipid Metabolism Disorders 173 8 Mitochondria 181 The Normal Mitochondrion 181 Mitochondrial Swelling: Response to Acute Injury 184 Mitochondriopathy of Metabolic and Chronic Diseases 188 Mitochondrial DNA-Based Disorders 193 Part III: Inflammation and Hemostasis 199 9 Endothelium 201 Endothelial Interface with Blood and Perivascular Space 201 Endothelial Thromboresistance vs. Procoagulation 206 Endothelial Response to Hypoxia and Circulatory Dysfunction 208 Inflammation 209 Mast Cell and Basophil Interface with Endothelium 217 Angiogenesis 223 10 Leukocytes and Platelets 231 The Neutrophil 231 Eosinophils 243 Platelets 246 Thrombosis 257 11 The Mononuclear Phagocyte System and Lymphocytes 269 The Monocyte-Macrophage System 269 Dendritic Cells 274 Lymphocytes 283 12 The Extracellular Matrix 295 Collagen Fibers 297 Microfibrils 303 Extracellular Ground Substance 304 Basement Membra...

List of contents

Part I: Structural Basis of Cell Injury
 
1. Response to Cellular Injury
 
2. Cell Death
 
3. Cellular Defense and Recovery
 

Part II: Organelle Pathology
 
4. The Cell Surface
 
5. Intracellular Trafficking
 
6. Nucleus, Ribosomes, the Golgi Complex, and Secretion
 
7. Peroxisomes, Smooth Endoplasmic Reticulum, and Lipids
 
8. Mitochondria
 

Part III: Infl ammation and Hemostasis
 
9. Endothelium
 
10. Leukocytes and Platelets
 
11. The Mononuclear Phagocyte System and Lymphocytes
 
12. The Extracellular Matrix
 

Part IV: Infectious Diseases
 
13. Cytopathology of Viral Diseases
 
14. Cytopathology of Pathogenic Prokaryotes
 
15. Pathogenic Protozoa
 
16. Algae, Fungi, and Other Eukaryotes
 

Part V: Toxicologic Diseases
 
17. Toxicologic Pathology
 
18. Myotoxins
 
19. Neurotoxins and Neurodegeneration
 
20. Nephrotoxins
 
21. Toxicity of Respiratory Systems
 

Part VI: Pathologic Growth
 
22. The Cell Cycle: Dysfunction in Aging, Senescence, and Hibernation
 
23. The Neoplastic Cell
 

Part VII: Diagnostic Pathology
 
24. Calcification
 
25. Pigments
 
26. Amyloid, Protein Misfolding Defects, and Inclusions
 
27. Metabolic and Storage Diseases
 
28. Arteriopathy
 
29. The Renal Glomerulopathies
 
30. Prions

Report

"The reorganization of the book, with complete tables of infectious agents and updated references, and the addition of illustrations to display complex cellular processes contribute to the book s value as a reference text. I highly recommend this book as a valuable resource for students, researchers, pathologists, and veterinary health-care professionals." ( Journal of the American Veterinary Medical Association , March 2010)

"This atlas has something for everyone: the student preparing for pathology boards, the bench pathologist, the diagnostician, and the toxicologic pathologist, just to name a few. This book, like the first edition, will be the gold standard desk reference for anyone who needs to interpret or confirm cellular changes from surgical or postmortem lesions." ( Microscopy & Microanalysis , 2010)

Product details

• Authors: Nf Cheville, Norman F Cheville, Norman F. Cheville, Norman F. (Iowa State University) Cheville, CHEVILLE NORMAN F, Cheville Norman F.
• Publisher: IOWA
• Languages: English
• Product format: Hardback
• Released: 05.06.2009
• EAN: 9780813803302
• ISBN: 978-0-8138-0330-2
• No. of pages: 1000
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Veterinary medicine; Veterinärmedizin, Pathologie, veterinary medicine, Veterinärmedizin / klinische Pathologie u. Labormedizin, Veterinary Clinical Pathology & Laboratory Medicine