Myocarditis - From Bench to Bedside

Myocarditis was last critically surveyed nearly a decade ago. During that time, our knowledge of viral-induced myocardial injury, autoimmune pathways in the heart, and the clinical treatment of myocarditis has advanced significantly. In Myocarditis: From Bench to Bedside, Leslie T. Cooper, Jr., md, has assembled a panel of leading clinical and scientific experts to comprehensively review this new knowledge, highlighting advances in both our basic scientific understanding and our current clinical knowledge of inflammatory heart disease. Topics covered span many disciplines, from the genetics of cardiotropic viral virulence to clinical epidemiology and treatment. On the clinical side the diagnosis, prognosis, and management of both nonspecific and specific myocarditis are extensively discussed in separate chapters devoted to such major idiopathic clinical entities as cardiac sarcoidosis, giant cell myocarditis, eosinophilic myocarditis, Chagas disease, rheumatic fever, and human immunodeficiency virus-related cardiomyopathy. Research articles complete the picture with discussions of the role of apoptosis in viral myocarditis, rat and mouse models of autoimmune giant cell and lymphocytic myocarditis, and the latest available data on enteroviral proteases and cardiomyopathy. Cutting-edge molecular methods of viral genome detection and both invasive and noninvasive diagnostic methods for viral and autoimmune myocarditis are also presented.
Multidisciplinary, state-of-the-art, and richly illustrated, Myocarditis: From Bench to Bedside is the first book to cover the entire spectrum of myocarditis from basic research to bedside medicine, providing today's researchers and clinicians a platform for understanding these diseases and today's significantly improved treatments for congestive heart failure, arrhythmias, and premature cardiovascular death.

List of contents

1. Introduction and Historical Perspective on Experimental Myocarditis.- 2. The Primary Viruses of Myocarditis.- 3. Cellular Autoimmunity in Myocarditis.- 4. Humoral Immune Response in Viral Myocarditis.- 5. Cytokines in Experimental Myocarditis.- 6. Nitric Oxide Signaling in Myocarditis.- 7. Life and Death Signaling Pathways in CVB3-Induced Myocarditis.- 8. Animal Models of Autoimmune Myocarditis.- 9. Progression of Myocarditis to Dilated Cardiomyopathy: Role of the Adrenergic System and Myocardial Catecholamines.- 10. Pathogenesis of Enteroviral Cardiomyopathy: Interaction of Viral Proteins With Infected Myocytes.- 11. Introduction to Clinical Myocarditis.- 12. Use of Cardiac Biomarkers for Detection of Myocarditis.- 13. Molecular Biologic Detection of Virus Infection in Myocarditis and Dilated Cardiomyopathy.- 14. Pathology of Human Myocarditis.- 15. Endomyocardial Biopsy in Myocarditis.- 16. Treatment of Lymphocytic Myocarditis.- 17. Idiopathic Giant Cell Myocarditis.- 18. Cardiac Sarcoidosis.- 19. The Eosinophil in Cardiac Disease.- 20. Chagas Heart Disease.- 21. Cardiac Involvement in Acute Rheumatic Fever.- 22. Myocarditis Associated With Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome.- 23. Childhood Myocarditis and Dilated Cardiomyopathy.- 24. Peripartum Cardiomyopathy.

Summary

Leslie T. Cooper, Jr., MD, and a panel of leading clinical and scientific experts comprehensively review both advances in basic scientific understanding and current clinical knowledge of inflammatory heart disease. On the clinical side they discuss the diagnosis, prognosis, and treatment of nonspecific and specific myocarditis in separate chapters devoted to such major idiopathic clinical entities as cardiac sarcoidosis, giant cell myocarditis, eosinophilic myocarditis, Chagas disease, rheumatic fever, and human immunodeficiency virus-related cardiomyopathy. Research articles complete the picture with discussions of the role of apoptosis in viral myocarditis, rat and mouse models of autoimmune giant cell and lymphocytic myocarditis, and the latest available data on enteroviral proteases and cardiomyopathy.

Additional text

"Perusal of this book shows that myocarditis is a very complex disease. There are various pathogenic mechanisms which are important in different patients. Much work remains to be done. This is an excellent book to review what we know at this time. This is a well-referenced book with more than 100 references and many chapters. There are 43 color plates and each chapter includes a short outline and an introductory and a concluding paragraph."-Doody's Health Sciences Book Review Journal

"...reaches its editor's goal to "cover the entire spectrum of myocarditis from basic research to bedside medicine" and "to foster exchange of new ideas between basic and clinical investigators." This multiauthored book contains a large amount of important information and can serve both as a reference and as an account of research in progress...The book is clearly written thoroughly referenced, and well organized, with highlighted headings. It is also well illustrated...I highly recommend this authoritative and very readable book. It is a valuable resource for any physician or scientist seeking to understand myocarditis." - NEW ENGLAND JOURNAL of MEDICINE

Report

"Perusal of this book shows that myocarditis is a very complex disease. There are various pathogenic mechanisms which are important in different patients. Much work remains to be done. This is an excellent book to review what we know at this time. This is a well-referenced book with more than 100 references and many chapters. There are 43 color plates and each chapter includes a short outline and an introductory and a concluding paragraph."-Doody's Health Sciences Book Review Journal

"...reaches its editor's goal to "cover the entire spectrum of myocarditis from basic research to bedside medicine" and "to foster exchange of new ideas between basic and clinical investigators." This multiauthored book contains a large amount of important information and can serve both as a reference and as an account of research in progress...The book is clearly written thoroughly referenced, and well organized, with highlighted headings. It is also well illustrated...I highly recommend this authoritative and very readable book. It is a valuable resource for any physician or scientist seeking to understand myocarditis." - NEW ENGLAND JOURNAL of MEDICINE

Product details

• Assisted by: COOPER (Editor), J Cooper (Editor), Jr Cooper (Editor), Jr. Cooper (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 17.04.2009
• EAN: 9781588291127
• ISBN: 978-1-58829-112-7
• No. of pages: 621
• Weight: 3 g
• Illustrations: XII, 621 p. 225 illus., 69 illus. in color.
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; B, Medicine, Cardiology