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Zusatztext "This book serves as an excellent introduction to biopharmaceuticals and as a source of references for those wanting more details."-Monique S.]. Simmonds! in The Journal of Experimental Agriculture! 2011! volume 47 (I)"Today! molecular farming represents an extremely heterogeneous field! due to the large variety of different production hosts examined and further complications derived from the different cultivation systems employed. ...the book provides a comprehensive overview of the different approaches taken over the last 20 years since the first heterologous expression of a monoclonal antibody in tobacco." -Dr. Stefan Jennewein! Fraunhofer Institute for Molecular Biology and Applied Ecology! in ChemMedChem! 2010. Informationen zum Autor Kathleen Laura Hefferon achieved her Ph.D. at the University of Toronto. She most recently held the title of Director of Operations of the Human Metabolic Research Unit in the Division of Nutritional Sciences at Cornell University. She also acts as a science writer for the Center for Hepatitis C Research at Rockefeller University in New York City and as an expert selector for the Infection and Immunity Division of the Medical Research Council, in London. Klappentext Designed as a basic reference for researchers in a wide variety of disciplines, this book discusses plant transformation techniques, the generation of transgenic plants, and the engineering of plant viruses to produce vaccine proteins or peptides. It addresses the basis of mucosal immunity using plant-based oral vaccines, organelle targeting for vaccine production, and the role of glycosylation in plant-made mammalian proteins. It also considers vaccine production in entire crops or in large batch cell suspension cultures as well as the development of clinical trials. The book concludes with a risk analysis and discussion of future applications. Zusammenfassung Discusses plant transformation techniques, the generation of transgenic plants, and the engineering of plant viruses to produce vaccine proteins or peptides. This title addresses the basis of mucosal immunity using plant-based oral vaccines, organelle targeting for vaccine production, and the role of glycosylation in plant-made mammalian proteins. Inhaltsverzeichnis History of Plants in Production of Biopharmaceuticals. Transgenic Plants Expressing Vaccine and Therapeutic Proteins. Chloroplast Engineering and Production of Biopharmaceuticals. Plant Viral Expression Vectors and Production of Biopharmaceuticals in Plants. Glycosylation of Therapeutic Proteins in Plants. Scale-Up of Plant-Derived Pharmaceuticals: Prospects for Commercial Production and for Global Health. The Immune Response to Plant-Derived Pharmaceuticals. Risk Analysis and Safety of Plant-Made Biopharmaceuticals. Epilogue: The Future. Index. ...
