Structural Genomics, Part B

Structural genomics is the systematic determination of 3-dimensional structures of proteins representative of the range of protein structure and function found in nature. This book examines the three dimensional structure of various proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy.

List of contents

Introduction; Analysis of genomes for structural genomics and the limitations of sequence analysis; Structure determination pipeline for structural genomics;Gene cloning and protein expression;Gene cloning and expression of membrane proteins; High-throughput protein purification for x-ray crystallography and NMR; High-throughput protein crystallization; Structure determination using synchrotron radiation; Application of NMR to structural genomics; Development of key high-throughput technologies: High-throughput functional screening; Development of key high-throughput technologies: Structure prediction and homology modeling; Functional inferences from structure; Structural genomics programs (SARS case); Structural genomics programs (E.coli);Structural genomics as a structural foundation for drug discovery; Structural genomics of eukaryote; Structural genomics of complexes; Dissemination structural genomics data to biology community

Product details

• Authors: Andrzej Joachimiak, Andrzej (EDT) Joachimiak
• Assisted by: Andrzej Joachimiak (Editor), Joachimiak Andrzej (Editor)
• Publisher: ELSEVIER SCIENCE BV
• Languages: English
• Product format: Hardback
• Released: 15.12.2009
• EAN: 9780123744425
• ISBN: 978-0-12-374442-5
• No. of pages: 112
• Series: Advances in Protein Chemistry and Structural Biology; Advances in Protein Chemistry; Advances in Protein Chemistry; Advances in Protein Chemistry and Structural Biology
• Subjects: Natural sciences, medicine, IT, technology > Biology > Biochemistry, biophysics; SCIENCE / Life Sciences / Biochemistry, SCIENCE / Life Sciences / Genetics & Genomics, biochemistry, proteins, Genetics (non-medical), Dna & Genome, SCIENCE / Bioinformatics, Computational biology / bioinformatics