Hematopoietic Stem Cell Transplantation

Remarkable developments in the field of transplantation have created opportunities to address the formidable challenges of transplantation across histocompatibility barriers, stem cell expansion, and prevention of complications and generation of graft-vs-tumor activity to eradicate residual disease. Stem Cell Transplantation for Hematologic and Other Disorders, Second Edition provides a glimpse into potential future applications of bone marrow derived stem cells in the field of cardiac repair. The updated chapters introduce the biologic underpinnings of hematopoietic cell transplantation, basic stem cell biology, immunobiology, and histocompatibility, with emphasis on indications and results of transplantation for specific diseases. Written by experts in the field, Stem Cell Transplantation for Hematologic Disorders, Second Edition provides seasoned professionals with a complete understanding of the current state of transplantation biology as well as a clear vision into the future.

List of contents

Biology of Transplantation.- Stem Cell Biology.- Stem Cell Transplantation for Hematologic Malignancies.- Immunobiology of Transplantation.- Transplantation for Specific Disorders.- Allogeneic and Autologous Hematopoietic Stem Cell Transplantation for Acute Lymphoblastic Leukemia and Acute Myelogenous Leukemia in the Adult.- Hematopoietic Cell Transplantation for Chronic Myeloid Leukemia.- Stem Cell Transplantation for Hodgkin's and Non-Hodgkin's Lymphomas.- Transplantation in Chronic Lymphocytic Leukemia.- Stem Cell Transplantation in Multiple.- Allogeneic Hematopoietic Cell Transplantation for Patients with Myelodysplastic Syndrome and Myeloproliferative Disorders.- Stem Cell Transplantation for Marrow Failure.- Stem Cell Transplantation for Hemoglobinopathies.- Alternative Stem Cell Sources.- Stem Cell Sources for Allogeneic Transplantation.- Allogeneic Unrelated Donor Blood and Marrow Transplantation.- Umbilical Cord Hematopoietic Stem Cell Transplantation.- Haploidentical Stem Cell Transplantation.- Conditioning Regimens.- Ablative Preparative Regimens for Hematopoietic Stem Cell Transplantation.- Nonmyeloablative Transplantation.- Complications of Transplantation.- Immune Reconstitution after Allogeneic Transplantation.- Infection in the Hematopoietic Stem Cell Transplant Recipient.- EBV Lymphoproliferative Disease after Transplantation.- Hepatic Veno-Occlusive Disease.- Lung Injury after Hematopoietic Stem Cell Transplantation.- Quality of Life Issues Post-Transplantation.- Graft-versus-Host Disease.- Pathophysiology of Acute Graft-versus-Host Disease.- Acute Graft-versus-Host Disease.- Chronic Graft-versus-Host Disease.- Immune Modulation.- Graft Manipulation: T Cell Depletion and Tumor Cell Purging.- Donor Lymphocyte Infusions Clinical Applications and the Graft?versus?Leukemia Effect.- Future Uses of Hematopoietic Stem Cells.- Regenerative Medicine: Application in Cardiovascular Diseases.

Summary

Remarkable developments in the field of transplantation have created opportunities to address the formidable challenges of transplantation across histocompatibility barriers, stem cell expansion, and prevention of complications and generation of graft-vs-tumor activity to eradicate residual disease. Stem Cell Transplantation for Hematologic and Other Disorders, Second Edition provides a glimpse into potential future applications of bone marrow derived stem cells in the field of cardiac repair. The updated chapters introduce the biologic underpinnings of hematopoietic cell transplantation, basic stem cell biology, immunobiology, and histocompatibility, with emphasis on indications and results of transplantation for specific diseases. Written by experts in the field, Stem Cell Transplantation for Hematologic Disorders, Second Edition provides seasoned professionals with a complete understanding of the current state of transplantation biology as well as a clear vision into the future.

Additional text

From the reviews of the second edition:
"This 2008 update of the previous book contains 9 new chapters as well as updates on basic stem biology, immunobiology … and the regenerative potential of stem cells. … Hematopoietic Stem Cell Transplantation is a worthwhile and valuable reference text appropriate for clinicians and researchers alike, since it represents the most up-to-date and concise information in the field." (Paulette Mehta, Journal of the American Medical Association, Vol. 301 (15), 2009)

“This book will be … interested to many immunologists. It is a reasonable guide to haematopoietic stem cell transplantation divided into five parts. … For the dedicated transplanter this is a useful book particularly if their interest is in haematological disease. There are … useful sections devoted to the immunological mechanisms involved in haematopoietic stem cell transplantation and some of the pathophysiological process underlying it. I feel the book will be … use to anyone but a specialist in the field.” (Andrew Gennery, Immunology News, February, 2010)

Report

From the reviews of the second edition:
"This 2008 update of the previous book contains 9 new chapters as well as updates on basic stem biology, immunobiology ... and the regenerative potential of stem cells. ... Hematopoietic Stem Cell Transplantation is a worthwhile and valuable reference text appropriate for clinicians and researchers alike, since it represents the most up-to-date and concise information in the field." (Paulette Mehta, Journal of the American Medical Association, Vol. 301 (15), 2009)
"This book will be ... interested to many immunologists. It is a reasonable guide to haematopoietic stem cell transplantation divided into five parts. ... For the dedicated transplanter this is a useful book particularly if their interest is in haematological disease. There are ... useful sections devoted to the immunological mechanisms involved in haematopoietic stem cell transplantation and some of the pathophysiological process underlying it. I feel the book will be ... use to anyone but a specialist in the field." (Andrew Gennery, Immunology News, February, 2010)

Product details

• Assisted by: Rober J Soiffer (Editor), Robert J Soiffer (Editor), Robert J Soiffer (Editor), Robert J. Soiffer (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 23.02.2011
• EAN: 9781934115053
• ISBN: 978-1-934115-05-3
• No. of pages: 736
• Weight: 1555 g
• Illustrations: XVI, 736 p. 17 illus. in color.
• Series: Contemporary Hematology; Contemporary Hematology
• Subject: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine