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Informationen zum Autor Robert Peter Chilcott, Senior Toxicologist, Chemical Hazards and Poisons Division HQ, Health Protection Agency, Chilton, UK. Shirley Price, Senior Lecturer in Toxicopathology, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK. Klappentext Written by experts in the field, Principles and Practice of Skin Toxicology provides a "bottom up" approach to studying skin toxicology. It provides a clear outline of basic concepts, citing both historical and modern references, and contains a glossary of key terms for quick and easy reference.Arranged in a user friendly and logical sequence, the book covers the five main areas of dermatotoxicology:* Principles of skin absorption. Explains the factors influencing dermal absorption and associated methods of measurement.* Methods for assessing skin toxicity. An overview of both in vivo and in vitro approaches to testing, with particular emphasis on the validation and use of alternative test strategies.* Clinical and occupational skin toxicity. A basic introduction to dermatology and related applications central to understanding dermal exposure to chemicals.* Regulatory aspects. An overview of national and international legislation governing the safe marketing of pharmaceuticals, cosmetics and industrial chemicals.This book will be especially useful to scientists who are new to the area of dermal toxicology, as well as practitioners of toxicology, clinical researchers, and researchers in industry and academia. Zusammenfassung Taking a "bottom up" approach to studying skin toxicology, this basic introduction to the principles and practice of dermal toxicology explores skin structure and function, principles and measurement of skin absorption, clinical aspects of dermal toxicity, and in vitro alternatives. Inhaltsverzeichnis Contents Foreword Preface Acknowledgements List of contributors PART I Introduction 1 Cutaneous anatomy and function Robert P. Chilcott 1.1 Introduction and scope 1.2 Surface features 1.3 Functional histology of the epidermis and associated structures 1.4 Species differences Summary References 2 Biochemistry of the skin Simon C. Wilkinson 2.1 Introduction and scope 2.2 Protein synthesis and organisation during epidermal differentiation 2.3 Lipid synthesis and organisation during epidermal differentiation 2.4 Lipid classes in the stratum corneum 2.5 Stratum corneum turnover 2.6 Biotransformations in skin Summary References 3 Skin photobiology Mark A. Birch-Machin and Simon C. Wilkinson 3.1 Introduction and scope 3.2 Photoprotection and melanogenesis 3.3 Increased environmental ultraviolet radiation exposure and its link with photoageing and skin cancer 3.4 Mitochondrial DNA as a biomarker of sun exposure in human skin 3.5 Apoptosis 3.6 Sun protection Summary References PART II Skin Absorption 4 Skin as a route of entry Simon C. Wilkinson 4.1 Salient anatomical features of the stratum corneum - the 'brick and mortar model' 4.2 Species and regional variation in skin structure 4.3 Species and regional variation in skin permeability 4.4 Intra- and inter-individual variation in percutaneous absorption 4.5 Effect of age on skin barrier function 4.6 Role of skin appendages 4.7 The in vitro skin sandwich model 4.8 Penetration of particles through appendages Summary References 5 Physicochemical Factors Affecting Skin Absorption Keith R. Brain and Robert P. Chilcott 5.1 Introduction 5.2 Physicochemical properties<...
