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Informationen zum Autor Khalid Iqbal is the editor of Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics , published by Wiley. Sangram S. Sisodia is the editor of Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics , published by Wiley. Bengt Winblad is the editor of Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics , published by Wiley. Klappentext Alzheimer's Disease is an ever-present problem affecting millions of people around the world and, as people's average lifespan lengthens, its prevalence is set to increase. A global effort is needed to combat the disease, including research to investigate the causes, development of effective treatments and, ultimately, prevention of the disease. Published every two years, these timely books discuss the very latest research. This new volume in the series: Provides a uniques source of reference to the important work being done in this field Gives academics and clinicians an opportunity to learn about cutting edge developments Covers all aspects of Alzheimer's Disease, including diagnosis, clinical course, epidemiological course and therapeutics and disease mechanisms. Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics and Therapeutics will provide essential information for basic and clinical researchers in Alzheimer's Disease and other dementias as well as for those who care for patients. Zusammenfassung Alzheimera s Disease is an ever present problem affecting millions of people around the world and! as peoplea s average lifespan lengthens! its prevalence is set to increase. A global effort is needed to combat the disease! including research to investigate the causes! development of effective treatments and! ultimately! prevention of the disease. Inhaltsverzeichnis List of Contributors xii Dedications xxvi Scientists Honored for Pioneering Research xxix Preface xxxv Acknowledgments xxxvi I. EPIDEMIOLOGY AND RISK FACTORS 1 1. The Transition from Normal Functioning to Dementia in the Aging Population 3 Laura Fratiglioni, Brent Small, Bengt Winblad and Lars Bäckman 2. Epidemiology of Alzheimer's Disease and Dementia: Advances and Challenges 11 Robert Katzman 3. Epidemiology of Dementia in Down's Syndrome 23 Nicole Schupf II. GENETICS 31 4. A Genomic Search for Alzheimer's Disease Genes 33 Jonathan L. Haines, L. Renee Bailey, Janet M. Grubber, Dale Hedges, Jenifer L. Hall, Sandra West, Leonard Santoro, Beth Kemmerer, Anne M. Saunders, Allen D. Roses, Gary W. Small, William K. Scott, P. Michael Conneally, Jeffery M. Vance and Margaret A. Pericak-Vance 5. Candidate Genes Showing No Evidence of Association with Alzheimer's Disease: Results of the NIMH-AD Genetics Initiative 45 Lars Bertram, Deborah Blacker, Adam S. Crystal, Jennifer Jones, Devon Keeney, Laura A. MacKenzie-Ingano, Kristina Mullin, Sanjay Basu, Stephen Yhu, Melvin McInnis, Rodney C. P. Go, Aleister J. Saunders and Rudolph E. Tanzi 6. Familial Alzheimer's Disease with Spastic Paraparesis Associated with a Mutation at Codon 261 of the Presenilin 1 Gene 53 Martin R. Farlow, Jill R. Murrell, Frederick W. Unverzagt, Michael Phillips, Masaki Takao, Christine Hulette and Bernardino Ghetti 7. Genetic Analysis of the Presenilin Pathway in Drosophila 61 Izhar Livne-Bar and Gabrielle L. Boulianne 8. Molecular Genetics and Transgenic Modeling of the Tauopathies 71 Jada Lewis, Matt Baker, Marjon Van Slegtenhorst and Mike Hutton 9. Regulation of Four-repeat tau Expression: Interactions between Exon and Intron Splicing Regulatory Sequences 87 Ian D'Souza and Gerard D. Schellenberg III. DIAGNOSIS ...
