High-Throughput Lead Optimization in Drug Discovery

Informationen zum Autor Tushar Kshirsagar Zusammenfassung Describes the application of parallel synthesis to lead optimization and the design and synthesis of targeted libraries. This book examines case studies that cover different biological targets. It explores the shift to conducting parallel lead optimization in-house while outsourcing the screening libraries synthesis. Inhaltsverzeichnis Introduction and Review. Application of Parallel Synthesis to the Optimization of Inhibitors of the ZipA-FtsZ Protein-Protein Interaction. Case Studies of Parallel Synthesis in Hit Identification! Hit Exploration! Hit-to-Lead! and Lead Optimization Programs. A Successful Application of Parallel Synthesis to Computer-Assisted Structural Optimization of New Leads Targeting Human Immunodeficiency Virus-1 Reverse Transcriptase: The Case of Acylthiocarbamates and Thiocarbamates. How High-Throughput Medicinal Chemistry Can Expedite Lead Discovery! Lead Optimization! and Beyond. Rapid Lead Identification of Inhibitors of Adenine Nucleotide Translocase: A Case Study of Applying Combinatorial Chemistry Techniques in Drug Discovery. Parallel Synthesis of Anticancer! Antiinflammatory! and Antiviral Agents Derived from L-and D-Amino Acids. Application of Solid-Phase Parallel Synthesis in Lead Optimization Studies. High-Throughput Solid-Phase Synthesis of Nucleoside-Based Libraries in the Search for New Antibiotics.

Product details

• Authors: Kshirsagar Kshirsagar, Tushar Kshirsagar, Tushar (3m Pharmaceuticals Kshirsagar, Tushar (EDT) Kshirsagar, Kshirsagar Tushar
• Assisted by: Tushar Kshirsagar (Editor), Tushar (3m Pharmaceuticals Kshirsagar (Editor), Kshirsagar Tushar (Editor)
• Publisher: Taylor & Francis Ltd.
• Languages: English
• Product format: Hardback
• Released: 04.03.2008
• EAN: 9780849372681
• ISBN: 978-0-8493-7268-1
• No. of pages: 256
• Dimensions: 184 mm x 254 mm x 19 mm
• Series: Critical Reviews in Combinatorial Chemistry; Critical Reviews in Combinatorial Chemistry
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Pharmacy; Medical research, MEDICAL / Pharmacy, SCIENCE / Chemistry / General, MEDICAL / Biotechnology, biotechnology, chemistry, Biology, life sciences, Pharmacology, Pharmaceutical technology, Pharmaceutical chemistry and technology