Read more
Informationen zum Autor Prof Sir Michael Rutter, King's College, London, UK Prof Rutter is the leading child psychiatrist in the UK. He set up the MRC Child Psychiatry Research Unit and the Institute of Psychiatry's Social, Genetic and Developmental Psychiatry Centre. He was Deputy Chairman of the Wellcome Trust from 1999 to 2004, and has been a Trustee of the Nuffield Foundation since 1992. He was elected a Fellow of the Royal Society in 1987 and an honorary member of the British Academy in 2002.?He was a Founding Fellow of the Academia Europaea and the Academy of Medical Sciences, of which he is currently Clinical Vice-President. He has published extensively. Klappentext While much research has attempted to show direct linear relations between genes and disorder, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. An alternative approach is to incorporate information about the environment. The gene-environment interaction approach focuses on the circumstances in which there is an environmental determinant of disease but where genes influence susceptibility to that environmental factor.Genetic Effects on Environmental Vulnerability to Disease is based on the final meeting of the Novartis Foundation Symposium Series (#293 Understanding How Gene Environment Interactions Work to Predict Disorder). Contributions from geneticists, physicians, oncologists, biologists, statisticians, epidemiologists, psychiatrists and psychologists address:* how physiological (mechanistic) measures can be better integrated into epidemiological cohort studies* how best to characterise subjects' vulnerability versus resilience by moving beyond genetic main effects* how gene hunters can benefit from recruiting samples selected for known exposures* how environmental pathogens can be used as tools for gene hunting* how to deal with potential spurious (statistical) interactions, and* how genes can help explain fundamental demographic properties of disorders such as sex distribution or age effects.Interwoven with transcripts of the lively discussions among researchers, the contents of the book offer a cutting-edge review of the methodological issues prevailing in this complex, multi-disciplinary field.A glossary of technical terms helps facilitate understanding across the different disciplines involved, and Sir Michael Rutter's introduction and concluding remarks contribute to presenting scientific issues in an interesting, easily accessible manner.This book will be of interest to epidemiologist, geneticists, developmental biologists, and researchers in psychiatric disorders, obesity, diabetes, cancer, respiratory diseases and cardiovascular disease Zusammenfassung Much research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment. Inhaltsverzeichnis 1. Michael Rutter Introduction: whither gene-environment interactions? 2. Rudolf Uher Gene-environment interaction: overcoming methodological challenges Discussion 3. Marco Battaglia! Cecilia Marino! Michel Maziade! Massimo Molteni and Francesca D'Amato Gene-environment interaction and behavioural disorders: a developmental perspective based on endophenotypes Discussion 4. Naomi R. Wray! William L. Coventry! Michael R. James! Grant W. Montgomery! Lindon J. Eaves and Nicholas G. Martin Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype! depression and stressful life events: an application of Item Response Theory Discussion Appendix General discussion I 5. Harold Snieder! Xiaoling Wang! Vasiliki Lagou! Brenda W. J. H. Penninx! Harriette Riese and Catharina A. Hartman Role of gene-stress interactions in gene-f...
