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Whenever the heart is challenged with an increased workload for a prolonged period, it responds by increasing its muscle mass - a phenomenon known as cardiac hypertrophy. Although cardiac hypertrophy is commonly seen under physiological conditions such as development and exercise, a wide variety of pathological situations such as hypertension (pressure overload), valvular defects (volume overload), myocardial infarction (muscle loss) and cardiomyopathy (muscle disease) are also known to result in cardiac hypertrophy.
The Hypertrophied Heart compiles state-of-the-art presentations in the area of molecular biology, cellular physiology and signal transduction in cardiac hypertrophy and heart failure to help in the formulation of new concepts and approaches for stimulating research. The book contains two sections: Mechanisms of Cardiac Hypertrophy, and Cardiac Failure in the Hypertrophied Heart. It is hoped that both students and scientists, as well as clinical and experimental cardiologists, will find this book useful in understanding the molecular and cellular events underlying the development of cardiac hypertrophy and the transition from cardiac hypertrophy to heart failure.
List of contents
Dedication. Preface. Acknowledgements. A: Mechanisms of Cardiac Hypertrophy. 1. Signal Transduction in Adapted Heart: Implication of Protein Kinase C-Dependent and -Independent Pathways; J. Debarros, D.K. Das. 2. Glucose-6-Phosphate Dehydrogenase: A Marker of Cardiac Hypertrophy; H.-G. Zimmer. 3. Regulation of Ribosomal DNA Transcription During Cardiomyocyte Hypertrophy; T. Arino, et al. 4. Mitochondrial Gene Expression in Hypertrophic Cardiac Muscles in Rats; T. Murakami, et al. 5. Serca2 and ANF Promoter-Activity Studies in Hypertrophic Cardiomyocytes using Liposome-, Gene Gun- and Adenovirus-Mediated Gene Transfer; K. Eizema, et al. 6. Ca 2+ Transients, Contractility and Inotropic Responses in Rabbit Volume-Overload Cardiomyocytes; K. Sakurai, et al. 7. Responsiveness of Contractile Elements to Muscle Length Change in Hyperthyroid Ferret Myocardium; T. Ishikawa, et al. 8. Contraction-Dependent Hypertrophy of Neonatal Rat Ventricular Myocytes: Potential Role for Focal Adhesion Kinase; D.M. Eble, et al. 9. Molecular Mechanism of Mechanical Stress-Induced Cardiac Hypertrophy; I. Komuro. 10. Possible Roles of the Tenascin Family During Heart Development and Myocardial Tissue Remodeling; K. Imanaka-Yoshida, et al. 11. Cardiac Cell-ECM Interactions: A Possible Site for Mechanical Signaling; S. Kanekar, et al. 12. Integrin-Dependent and -Independent Signaling During Pressure Overload Cardiac Hypertrophy; M. Laser, et al. 13. Role of G-Proteins in Hypertension and Hypertrophy; M. Anand-Srivastava, F. di Fusco. 14. Three-Dimensional Nuclear Size and DNA Content in Hypertensive Heart Disease; A. Takeda, et al.
