RNA Technologies in Cardiovascular Medicine and Research

In this book the authors review the field and explore the potential role of RNAi and other RNA technologies in cardiovascular medicine and research. They highlight the impressive recent progress but also the hurdles that still must be overcome before this promising technology is finally ready for translation and clinical use.

List of contents

MicroRNA.- An Overview of MicroRNA.- MicroRNAs and Their Potential.- miRNAs and Their Emerging Role in Cardiac Hypertrophy.- MicroRNAs and the Control of Heart Pathophysiology.- MicroRNA Systems Biology.- RNA Interference.- Targeting Viral Heart Disease by RNA Interference.- Design of siRNAs and shRNAs for RNA Interference: Possible Clinical Applications.- RNA Interference and MicroRNA Modulation for the Treatment of Cardiac Disorders.- Cardiac Delivery of Nucleic Acids by Transcriptional and Transductional Targeting of Adeno-Associated Viral Vectors.- Ribozymes.- Characterization of Hammerhead Ribozymes Potentially Suitable for the Treatment of Hyper-Proliferative Vascular Diseases.- Applications of Ribozymes and Pyrrole-Imidazole Polyamides for Cardiovascular and Renal Diseases.- Noncoding, Aptamer and Antisense RNAs.- Noncoding RNAs in Human Diseases.- Aptamers and siRNAs in Cardiovascular Disease.- Nucleic Acid Aptamers for Cardiovascular Therapeutics.- NF?B Decoy Oligodeoxynucleotide-Based Therapy in Cardiovascular Diseases.- Antisense Therapy for Restenosis Following Percutaneous Coronary Interventions.- Toxic RNA in Pathogenesis of Human Neuromuscular Disorders.

Summary

In this book the authors review the field and explore the potential role of RNAi and other RNA technologies in cardiovascular medicine and research. They highlight the impressive recent progress but also the hurdles that still must be overcome before this promising technology is finally ready for translation and clinical use.

Product details

• Assisted by: Jan Barciszewski (Editor), Volker A. Erdmann (Editor), Volker A. Erdmann (Deceased) (Editor), Wolfgan Poller (Editor), Wolfgang Poller (Editor), Wolfgang 10001005026 Poller (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 14.04.2009
• EAN: 9783540787082
• ISBN: 978-3-540-78708-2
• No. of pages: 358
• Dimensions: 155 mm x 24 mm x 235 mm
• Weight: 672 g
• Illustrations: XIV, 358 p. 55 illus.
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; Biochemie, B, Translation, Genetik, Medizin, Transcription, Life Sciences, biochemistry, molecular biology, Human Genetics, Biomedical and Life Sciences, Medical Genetics, Biochemistry, general, Biomedical Research, Molecular Medicine, vascular disease, ribozyme