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Informationen zum Autor Yehuda Shoenfeld is the Incumbent of the Laura Schwarz-Kipp Chair of Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel Aviv University in Tel Aviv, Israel. He is also Founder of the Center for Autoimmune Diseases, both at the Sheba Medical Center in Tel Hashomer, Israel. Klappentext Only in very recent times have therapies been developed that are specific to a particular manifestation of autoimmune disease, and these have begun to replace the all-purpose remedies of the past 30 years. This volume, which draws on the principles of immunology presented in Volume 1050 ( Autoimmunity: Concepts and Diagnosis at the Cutting Edge ), extends these concepts to the realm of clinical findings and current therapy for many autoimmune and connective tissue disorders. Both organ-specific and organ-nonspecific diseases are covered, and one section is entirely focused on treatment. Treatments using cytokines, chemokines, cognate receptors, and genetic interactions are particularly prominent in these reports, and attention is also paid to the increasing use of intravenous imunoglobulins and both monoclonal and imunosuppressive agents. A therapeutic void remains, but the work reported on here contributes considerably to the effort to fill that void. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member. Zusammenfassung Only in very recent times have therapies been developed that are specific to a particular manifestation of autoimmune disease! and these have begun to replace the all-purpose remedies of the past 30 years. Inhaltsverzeichnis Foreword: Yehuda Shoenfeld and M. Eric Gershwin. . Part I: Organ-Specific Autoimmune Diseases:. 1. Activation, Apoptosis, and Clearance of Neutrophils in Wegener's Granulomatosis: André P. van Rossum, Pieter C. Limburg, and Cees G. M. Kallenberg. 2. Is PR3-ANCA Formation Initiated in Wegener's Granulomatosis Lesions? Granulomas as Potential Lymphoid Tissue Maintaining Autoantibody Production: J Voswinkel, A Müller, and P Lamprecht. 3. Clinical Relevance of Antiphospholipid Antibodies in Primary Biliary Cirrhosis: Philipp von Landenberg, Michael Baumgartner, Juergen Schoelmerich, Karl J. Lackner, and Reinhild Klein. 4. IL-10 and the Cytokine Network in the Pathogenesis of Human Autoimmune Hemolytic Anemia: Caterina Toriani-Terenzi and Enzo Fagiolo. 5. Crohn's Disease Is Associated with Polymorphism of CARD15/NOD2 Gene in a Hungarian Population: Zsuzsanna Nagy, Oszkár Karádi, György Rumi, György Rumi, Jr., Alajos Pár, Gyula Mózsik, László Czirják, and Gábor Süto. 6. Apoptosis in Human Skin: Role in Pathogenesis of Various Diseases and Relevance for Therapy: Esther Reefman, Pieter C. Limburg, Cees G. M. Kallenberg, and Marc Bijl. 7. Cancer-Associated Myositis: Clinical Features and Prognostic Signs: Andrea Ponyi, Tamás Constantin, Miklós Garami, Csilla andrás, Béla Tállai, Andrea Váncsa, Lajos Gergely, and Katalin Dankó. 8. Control of Type 1 Autoimmune Diabetes by Naturally Occurring CD4+CD25+ Regulatory T Lymphocytes in Neonatal NOD Mice: C A Piccirillo, M Tritt, E Sgouroudis, A Albanese, M Pyzik, and V Hay. 9. The Role of Methallothioneins in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis: Carmen Espejo and Eva M. Martínez-Cáceres. 10. Oxidized Low-Density Lipoprotein/ß2-Glycoprotein I Complexes ...
