Read more
Informationen zum Autor Yoon S. Cho-Chung and Alan M. Gewirtz are the authors of Therapeutic Oligonucleotides: Transcriptional and Translational Strategies for Silencing Gene Expression, Volume 1058, published by Wiley. Klappentext The potential for the development of therapeutic oligonucleotides into clinical medicines and their use as basic research tools are explored in this volume, which is the proceedings of the 7th NIH Symposium on Therapeutic Oligonucleotides. The focus is on antisense, RNAi, triple-helix, gene repair, DNA chips, and CpG immune modulatory oligonucleotides. Specific chapters address designing better siRNAs, splice switching oligonucleotides, selective delivery of oligonucleotides, and medicinal drugs by receptor-mediated endocytosis, development of a function overriding siRNA silencing in mammalian cells, transcription factor decoys, and modified oligonucleotide hybridization and genetic insertion. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member. Zusammenfassung The potential for the development of therapeutic oligonucleotides into clinical medicines and their use as basic research tools are explored in this volume! which is the proceedings of the 7th NIH Symposium on Therapeutic Oligonucleotides. Inhaltsverzeichnis Introduction: Y S Cho-Chung, Alan M. Gewirtz, and Cy A. Stein. Part I: Kill the Messenger: Gene Silencing by Nucleic Acid Molecules. 1. Knock-down of the Cytoprotective Gene, Clusterin, to Enhance Hormone and Chemosensitivity in Prostate and Other Cancers: Martin Gleave and Kim N. Chi. 2. Recognition of Chromosomal DNA in Human Cells by Peptide Nucleic Acids and Small Duplex RNAs: David R. Corey. Part II: Antisense and siRNA: Chemistry, Sequence Specificity, and Target Validation. 3. Design and Development of Thermolytic DNA Oligonucleotide Prodrugs: Andrzej Grajkowski, Joao Pedras-Vasconcelos, Cristina Ausín, Daniela Verthelyi, and Serge L. Beaucage. 4. Rationally Targeted, Conformationally Constrained, Oxetane-Modified Oligonucleotides Demonstrate Efficient Gene-Silencing Activity in a Cellular System: J B Opalinska and A M Gewirtz. Part III: Delivery Cellular and Phenotype Effect of Silencing Agents:. 5. In Vivo Potentialities Andrei Maksimenko, Valerie Polard, Marie Villemeur, Hind Elhamess, Patrick Couvreur, Jean-Remi Bertrand, Malam Aboubakar, Marina Gottikh, and Claude Malvy of EWS-Fli-1 Targeted Antisense Oligonucleotides-Nanospheres Complexes:. 6. Endo-Porter: A Novel Reagent for Safe, Effective Delivery of Substances into Cells: James E. Summerton. 7. Tumor Reversion: Protein Kinase A Isozyme Switching: Yoon S. Cho-Chung and Maria V. Nesterova. Part IV: Immune Modulation of and Resistance to Silencing Agents. 8. Therapeutic Potential of Oligonucleotides Expressing Immunosuppressive TTAGGG Motifs: Dennis M. Klinman, Ihsan Gursel, Sven Klaschik, Li Dong, Debbie Currie, and Hidekazu Shirota. 9. Breaking Tolerance to Tumors with Dendritic Cell-Based Immunotherapy: Ines Mende and Edgar G. Engleman. 10. Development of Resistance to RNAi in Mammalian Cells: Zhi-Ming Zheng, Shuang Tang, and Mingfang Tao. Part V: Transcription Silencing by Nucleic Acid Molecules. 11. The Development of Bioactive Triple Helix-Forming Oligonucleotides: Michael M. Seidman, Nitin Puri, Alokes Majum...
