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Informationen zum Autor Samuel Sideman, Rafael Beyar, Amir Landesberg All of the Israel Institute of Technology, Haifa, Israel Klappentext The basic phenomena of intra- and intercellular communication and the transport signals within and between the cells controlling cardiac function are described and discussed in this volume. The amazing synchronization of millions of cells and billions of nanoscale molecular motors, ion gates, and ion pumps assure normal cardiac function; whereas disharmony and local transport and signal disruptions are the forecasters, and eventual causes, of pathologic conditions and heart failure. Although this volume concentrates on basic phenomena, strong emphasis is given to the related clinical and pharmaceutical manifestations, and chapters have been contributed by molecular biologists, pharmaceutical experts, and cardiac scientists. This volume will promote better understanding and, consequently, better clinical and pharmaceutical handling of the various aspects of cardiac pathophysiologies associated with electrical, mechanical, and metabolic and circulatory disorders in the cardiovascular system. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member. Zusammenfassung The basic phenomena of intra- and intercellular communication and the transport signals within and between the cells controlling cardiac function are described and discussed in this volume. Inhaltsverzeichnis Preface: The Cellular Communications Maze: Samuel Sideman. . Part I: Prologue:. 1. From Organ to Molecules: Steps and Consequences: Rafael Beyar. . Part II: Cardiac Cell Development:. 2. Evolution of the Heart from Bacteria to Man: Nanette H. Bishopric. 3. The Miscommunicative Cardiac Cell: When Good Proteins Go Bad: Aldrin V. Gomes, Gayathri Venkatraman, and James D. Potter. 4. Multiple Stem Cell Populations Contribute to the Formation of the Myocardium: Leonard M. Eisenberg, Ricardo Moreno, and Roger R. Markwald. 5. Differentiation Pathways in Human Embryonic Stem Cell-Derived Cardiomyocytes: Sophie Lev, Izhak Kehat, and Lior Gepstein. 6. Functional Properties of Human Embryonic Stem Cell-Derived Cardiomyocytes: Katya Dolnikov, Mark Shilkrut, Naama Zeevi-Levin, Asaf Danon, Sharon Gerecht-Nir, Joseph Itskovitz-Eldor, and Ofer Binah. . Part III: Calcium Signaling:. 7. The Assembly of Calcium Release Units in Cardiac Muscle: Clara Franzini-Armstrong, Feliciano Protasi, and Pierre Tijskens. 8. Calcium Signaling in Cardiac Ventricular Myocytes: Donald M. Bers and Tao Guo. 9. Calcium Biology of the Transverse Tubules in Heart: Long-Sheng Song, Silvia Guatimosim, Leticia Gómez-Viquez, Eric A. Sobie, andrew Ziman, Hali Hartmann, and W. J. Lederer. 10. Multimodality of Ca2+ Signaling in Rat Atrial Myocytes: Martin Morad, Ashkan Javaheri, Tim Risius, and Steve Belmonte. 11. Effects of Na+-Ca2+ Exchange Expression on Excitation-Contraction Coupling in Genetically Modified Mice: Joshua I. Goldhaber, Scott A. Henderson, Hannes Reuter, Christian Pott, and Kenneth D. Philipson. 12. Mitochondrial Calcium Signaling and Energy Metabolism: My-Hanh T. Nguyen and M. Saleet Jafri. 13. Rhythmic Ca2+ Oscillations Drive Sinoatrial Nodal Cell Pacemaker Function to Make the Heart Tick: Tatiana M. Vinogradova, Victor A....
