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Informationen zum Autor Matthew P. Hardy and Michael Griswold are the authors of Testicular Cell Dynamics and Endocrine Signaling, Volume 1061, published by Wiley. Klappentext The past few years have brought an influx of new information into the field of male reproduction. Several laboratories have been able to apply the genomics approach to gene expression in the male, revealing previously unknown patterns of gene expression and gene products that were localized in male reproductive tract tissues and cells for the first time. These discoveries paved the way for the next wave, an opportunity to analyze male reproductive biology and the processes by which sperm are formed in the seminiferous tubule and androgen is synthesized in the interstitium of the testis. The different levels of organization in the testis, including the stages of spermatogenesis, enzymatic steps of steroidogenesis, and the intracellular signaling pathways of hormones, are now more amenable to study and selection of potential targets for drug development. This volume capitalizes on these developments with a collection of reports that is uniquely suited to stimulate research and development ideas. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member. Zusammenfassung The different levels of organization in the testis! including the stages of spermatogenesis! enzymatic steps of steroidogenesis! and the intracellular signaling pathways of hormones! are now more amenable to study and selection of potential targets for drug development. Inhaltsverzeichnis Preface: Matt Hardy and Mike Griswold. Part I: Development. 1. Hormonal Regulation of Male Reproductive Tract Development. (Sunita Verma-Kurvari, Serge Nef, and Luis F. Parada). 2. Sox9 in Testis Determination. (Akio Kobayashi, Hao Chang, Marie-Christine Chaboissier, Andreas Schedl, and Richard R. Behringer). 3. Seminiferous Cord Formation and Germ-Cell Programming: Epigenetic Transgenerational Actions of Endocrine Disruptors. (Michael K. Skinner and Matthew D. Anway). 4. In Vitro Generation of Germ Cells: New Techniques to Solve Current Issues. (Joshua M. Baughman and Niels Geijsen). Part II: The Endocrine Axis. 5. Structure-Function Relationships of the Luteinizing Hormone Receptor. (David Puett, Yongsheng Li, Krassimira Angelova, Geneva Demars, Thomas P. Meehan, Francesca Fanelli, and Prema Narayan). 6. Transgenic Rescue of SF-1-Null Mice. (Tatiana Karpova, R. R. M. Maran, Jeremy Presley, Serge P. Scherrer, Lovella Tejada, and Leslie L. Heckert). 7. Estrogens in Testis Biology. (Jayne E. Sierens, Sharon F. Sneddon, Frances Collins, Michael R. Millar, and Philippa T. K. Saunders). 8. Foxa1 and Foxa2 Interact with the Androgen Receptor to Regulate Prostate and Epididymal Genes Differentially. (Xiuping Yu, Aparna Gupta, Yongqing Wang, Kichiya Suzuki, Janni Mirosevich, Marie-Claire Orgebin-Crist, and Robert J. Matusik). 9. Role of Glial Cell Line-Derived Neurotrophic Factor in Germ-Line Stem Cell Fate. (Laura Braydich-Stolle, Courtney Nolan, Martin Dym, and Marie-Claude Hofmann). Part III: Steroidogenesis. 10. P450 Oxidoreductase Deficiency: A New Disorder of Steroidogenesis. (Walter L. Miller, Ningwu Huang, Amit V. Pandey, Christa E. Flück, and Vishal Agrawal). 11. Neuroendocrine Regulation of Leydig Cell Development. (P. J. O'shaughness...
