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Informationen zum Autor Jitka Ourednik born Hanzíkov&á is a natural scientist of Czech origin now living in Switzerland. She is a daughter of the Czech contemporary sculptor Stanislav Hanzik. Vaclav Ourednik is the editor of Stem Cell Biology: Development and Plasticity, Volume 1049, published by Wiley. Klappentext Cover art Various cell surface receptors mediate an intimate dialogue between stem cells and their environment and can modulate the behavior of both in decisive ways. The over-expression of such molecules in neural stem cells can lead to elaborate neurite outgrowth from differentiating neurons. The examples shows a large neuron (body size over 30 um) in culture over-expressing the neural cell recognition molecule L1 and communicating with other cellular partners. Nuclei of cultured cells are visualized by the fluorescent marker DAPI (blue) and the neurons by immunofluorescent staining against the early neuronal antigen BIII-tubulin (red). Microphotograph taken by Dr. Ying-Zhi Xu from the Ourednik Lab of Stem Cell Plasticity and Neural Transplantation, Iowa State University, Ames, Iowa. Zusammenfassung Stem cells have generated considerable interest recently in the scientific! clinical! and public arenas. It is essential that we gain a broader understanding of the factors that regulate the biology of stem cells: their ability for self-renewal! differentiation! and plasticity! as well as the differences between embryonic and adult stem cells. Inhaltsverzeichnis Preface: Jitka Ourednik, Václav Ourednik, Donald Sakaguchi, and Marit Nilsen-Hamilton. Part I: Regional Determinants of Cell Fate:. 1. Oxygen in the Cultivation of Stem Cells. By Marie Csete. 2. DNA Damage-Induced Programmed Cell Death: Potential Roles in Germ Cell Development. By Yukiko Yamada and Clark R. Coffman. . Part II: Intrinsic Determinants of Stem Cells:. 3. G Protein-Coupled Receptor Roles in Cell Migration and Cell Death Decisions: Angela R. Kamps and Clark R. Coffman. 4. Growth and Differentiation of Astrocytes and Neural Progenitor Cells on Micropatterned Polymer Films: Jennifer B. Recknor, D S. Sakaguchi, and S K. Mallapragada. 5. Cellular and Molecular Regulation of Hematopoietic and Intestinal Stem Cell Behavior: Xi C. He, Jiwang Zhang, and Linheng Li. 6. The Function of the Neuronal Proteins Shc and Huntingtin in Stem Cells and Neurons: Pharmacologic Exploitation for Human Brain Diseases: Chiara Zuccato, Luciano Conti, Erika Reitano, Marzia Tartari, and Elena Cattaneo. 7. Engineering a Dopaminergic Phenotype in Stem/Precursor Cells: Role of Nurr1, Glia-Derived Signals, and Wnts: Ernest Arenas. . Part III: Transdifferentiation:. 8. Umbilical Cord Blood-Derived Stem Cells and Brain Repair: Paul R. Sanberg, Alison E. Willing, Svitlana Garbuzova-Davis, Samuel Saporta, Guoqing Liu, Cyndy Davis Sanberg, Paula C. Bickford, Stephen K. Klasko, and Nagwa S. El-Badri. 9. Infusion of Human Umbilical Cord Blood Ameliorates Neurologic Deficits in Rats with Hemorrhagic Brain Injury: Zhenhong Nan, andrew Grande, Cyndy D. Sanberg, Paul R. Sanberg, and Walter C. Low. 10. How Wnt Signaling Affects Bone Repair by Mesenchymal Stem Cells from the Bone Marrow: Carl A. Gregory, William G. Gunn, Emigdio Reyes, Angela J. Smolarz, James Munoz, Jeffrey L. Spees, and Darwin J. Prockop. . Part IV: Stem Cell Responses to Perturbation:. 11. Human Retinal Progenitor Cells Grown as Neurospheres Demonstrate Time-Dependent Changes in Neuronal and Glial Cell Fate Potential: David M. Gamm, Aaron D. Nelson, and Clive N. Svendsen. 12. Neural Progenitor Cell Transplants into the Developing and Mature Central Nervous System: D S. Sakaguchi, S J. Van Hoffelen, S D. Grozdanic, Y H. Kwon, R H. Kardon, and M J. Young. 13. Stem Cells for Retinal Degenerative Disord...
