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Informationen zum Autor Yau-Huei Wei is the editor of The Role of Mitochondria in Human Aging and Disease: From Genes to Cell Signaling, Volume 1042, published by Wiley. Horng-Mo Lee is the editor of The Role of Mitochondria in Human Aging and Disease: From Genes to Cell Signaling, Volume 1042, published by Wiley. Klappentext Virtually every aspect of mitochondrial research and medicine is addressed in this volume, including mitochondrial function and dysfunction, free radical biology relevant to mitochondrial dysfunction, the role of mitochondria in apoptosis, and abnormal signaling processes and disease mechanisms associated with aging, mtDNA mutations, or mitochondrial damage. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member. Zusammenfassung Addresses the various aspects of mitochondrial research and medicine! including mitochondrial function and dysfunction! free radical biology relevant to mitochondrial dysfunction! the role of mitochondria in apoptosis! and abnormal signaling processes and disease mechanisms associated with aging! mtDNA mutations! or mitochondrial damage. Inhaltsverzeichnis Preface: Yau-Huei Wei, Horng-Mo Lee, and Chung Y. Hsu. Part I: Mitochondrial Disease Models:. 1. Mitochondria-Based Model for Fetal Origin of Adult Disease and Insulin Resistance: Hong Kyu Lee, Kyong Soo Park, Young Min Cho, Yun Yong Lee, and Youngmi Kim Pak. 2. Evolutional Analysis in Determining Pathogenic versus Nonpathogenic Mutations of ATPase 6 in Human Mitochondriopathy: Chin-Yuan Tzen and Tsu-Yen Wu. 3. Restoration of Mitochondrial Function in Cells with Complex I Deficiency: Yidong Bai, Jeong Soon Park, Jian-Hong Deng, Youfen Li, and Peiqing Hu. 4. Hearing Loss in Mitochondrial Disorders: Chang-Hung Hsu, Haeyoung Kwon, Cherng-Lih Perng, Ren-Kui Bai, Pu Dai, and Lee-Jun C. Wong. 5. Brain Single Photon Emission Computed Tomography in Patients with A3243G Mutation in Mitochondrial DNA tRNA: Peterus Thajeb, Ming-Che Wu, Bing-Fu Shih, Chin-Yuan Tzen, Ming-Fu Chiang, and Rey-Yue Yuan. 6. Upregulation of Matrix Metalloproteinase 1 and Disruption of Mitochondrial Network in Skin Fibroblasts of Patients with MERRF Syndrome: Yi-Shing Ma, Yin-Chiu Chen, Ching-You Lu, Chun-Yi Liu, and Yau-Huei Wei. 7. Increased Oxidative Damage with Altered Antioxidative Status in Type 2 Diabetic Patients Harboring the 16189 T to C Variant of Mitochondrial DNA: Tsu-Kung Lin, Shang-Der Chen, Pei-Wen Wang, Yau-Huei Wei, Cheng-Feng Lee, Tzu-Ling Chen, Yao-Chung Chuang, Teng-Yeow Tan, Ku-Chou Chang, and Chia-Wei Liou. 8. Alteration of the Copy Number of Mitochondrial DNA in Leukocytes of Patients with Hyperlipidemia: Chin-San Liu, Ching-Ling Kuo, Wen-Ling Cheng, Ching-Shan Huang, Cheng-Feng Lee, and Yau-Huei Wei. 9. A New Noninvasive Test to Detect Mitochondrial Dysfunction of Skeletal Muscles in Progressive Supranuclear Palsy: Yung-Yee Chang, Chiang-Hsuan Lee, Min-Yu Lan, Hsiu-Shan Wu, Chiung-Chih Chang, and Jia-Shou Liu. 10. High Prevalence of the COII/tRNALys Intergenic 9-bp Deletion in Mitochondrial DNA of Taiwanese Patients with MELAS or MERRF Syndrome: Chin-San Liu, Wen-Ling Cheng, Yi-Yun Chen, Yi-Shing Ma, Cheng-Yoong Pang, and Yau-Huei Wei. . Part II: Mitochondrial Genome:. 11. Analysis of Proteome Bound to D-Loop Region of Mitochondrial DNA by DNA-Linked Affinity Chromatography and R...