Airway Smooth Muscle in Asthma and Copd - Biology and Pharmacology

Informationen zum Autor K Fan Chung , Professor, Experimental Studies Group, Royal Brompton Campus; Editorial Board member of American Journal Respiratory Critical Care Medicine, Respirology Klappentext Airway Smooth Muscle in Asthma and COPDBIOLOGY AND PHARMACOLOGYEDITORK. Fan ChungAirway Disease Section, National Heart & Lung Institute, College LondonAirway Smooth Muscle in Asthma and COPD is the first book of its kind that focuses entirely on the airway smooth muscle as the prime abnormality in airways diseases such as asthma.Airways diseases are significant cause of morbidity and mortality across the world, and increasing research into these diseases has developed the understanding of pathophysiological processes in airways disease, such that there is now greater hope for new and more effective treatments. At the heart of this increased understanding is the important contribution of the airway smooth muscle that not only underlies the acute and chronic airway narrowing found in these diseases, but also contributes to the inflammatory and remodelling changes of airway diseases.Professor Chung has published extensively on the pathophysiology of airways diseases and on airway smooth muscle biology and the contributors are all researchers in their specific fields. This volume will provide understanding for specialist physicians in pulmonology and allergy, workers in biomedical and pharmaceutical research, clinical investigators in pulmonary disease and scientists, of the approaches to discovering newer effective therapies for airways disease which will remain an important challenge for many years to come.This book brings together under the same cover the biology and pharmacology of the airway smooth muscle in health and disease, particularly focusing on asthma and COPD, explaining:* How abnormalities form the basis of many pathophysiological abnormalities of airways diseases such as asthma and COPD* Evidence for the participation of the airway smooth muscle in the inflammatory and remodelling response of the airways* Mechanisms of action of currently-available treatments on airway smooth muscle is particularly emphasized and potential targets for the treatment of airway diseases are highlighted Zusammenfassung In this book, leading researchers in medicine and molecular pharmacology explain the cellular mechanisms that control airway smooth muscle. The means by which these are disrupted in disease, and the pharmacologic strategies by which they may be modified are discussed and future therapeutic interventions are identified. Inhaltsverzeichnis List of Contributors xi 1 Biophysical basis of airway smooth muscle contraction and hyperresponsiveness in asthma 1 Steven S. An and Jeffrey J. Fredberg 1.1 Introduction 1 1.2 Airway hyperresponsiveness 2 1.3 Classical behaviour of airway smooth muscle and the balance of static forces 6 1.4 Shortening velocity and other manifestations of muscle dynamics 8 1.5 Biophysical characterization of airway smooth muscle: bronchospasm in culture? 10 1.6 Mechanical plasticity: a nonclassical feature of airway smooth muscle 14 1.7 Recent observations 18 1.8 Future directions 20 References 20 2 Dynamics of cytoskeletal and contractile protein organization: an emerging paradigm for airway smooth muscle contraction 31 Wenwu Zhang and Susan J. Gunst 2.1 Introduction 31 2.2 Molecular structure and organization of contractile and cytoskeletal filaments in the airway smooth muscle cell 33 2.3 Cytoskeletal dynamics and airway smooth muscle contraction 38 References 43 3 Airway smooth muscle: role in airway constrictor hyperresponsiveness 53 Melanie Brown and Julian Solway 3.1 What is airway constrictor hyperresponsiveness (AHR)? 53 3.2 Is AHR ever good? 55...

List of contents

List of Contributors.
 
1. Biophysical basis of airway smooth muscle contraction and hyperresponsiveness in asthma (Steven S. An and Jefferey J. Fredberg).
 
References.
 
2. Dynamics of cytoskeletal and contractile protein organization: an emerging paradigm for airway smooth muscle contraction (Wenwu Zhang and Susan J. Gunst).
 
References.
 
3. Airway smooth muscle: role in airway constrictor hyperresponsiveness (Melanie Brown and Julian Solway).
 
Acknowledgements.
 
References.
 
4. Airway smooth muscle phenotypic and functional plasticity (Andrew J. Halayko, Reinoud Gosens and Thai Tran).
 
References.
 
5. Airway smooth muscle proliferation: insights into mechanisms regulating airway smooth muscle mass (Reynold A. Panettieri, Jr.).
 
References.
 
6. Airway smooth muscle bidirectional interactions with extracellular matrix (Jane E. Ward and Stuart J. Hirst).
 
Acknowledgements.
 
References.
 
7. Airway smooth muscle interaction with mast cells (Roger Marthan, Patrick Berger, Pierre-Olivier Girodet and J. Manuel Tunon-de-Lara).
 
Acknowledgements.
 
References.
 
8. Airway smooth muscle synthesis of inflammatory mediators (Alison E. John, Deborah L. Clarke, Alan J. Knox and Karl Deacon).
 
References.
 
9. Airway smooth muscle in experimental models (Anne-Marie Lauzon and James G. Martin).
 
Acknowledgement.
 
References.
 
10. Altered properties of airway smooth muscle in asthma (Judith Black, Janette Burgess, Brian Oliver and Lyn Moir).
 
References.
 
11. The airway smooth muscle in chronic obstructive pulmonary disease (COPD) (Maria B. Sukkar and Kian Fan Chung).
 
References.
 
12. Glucocorticoid actions on airway smooth muscle (Ian M. Adcock, Loukia Tsaprouni and Pank Bhavsar).
 
Acknowledgements.
 
References.
 
13. ß2-Adrenergic receptors: effects on airway smooth muscle (Malcolm Johnson).
 
References.
 
14. Asthma treatments: effects on the airway smooth muscle (Kian Fan Chung).
 
Index.

Report

Aimed at specialists in pulmonology, this volume provides the clinician with the most up to date information on one of the core physiological processes in airway disease, and offers insights into current and future approaches to management. ( Doody s Reviews , March 2009)

Product details

• Authors: F Chung, Kian Fan Chung, Kian Fan (Experimental Studies Group) Chung, CHUNG KIAN FAN
• Assisted by: Kian Fan Chung (Editor)
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 18.04.2008
• EAN: 9780470060667
• ISBN: 978-0-470-06066-7
• No. of pages: 326
• Subjects: Natural sciences, medicine, IT, technology > Biology; Medizin, Linguistik, Immunologie, Immunology, Life Sciences, KARDIOVASKULÄRE ERKRANKUNGEN, Biowissenschaften, Zell- u. Molekularbiologie, Cell & Molecular Biology, Medical Science, Kardiovaskuläre Erkrankung, Anatomy & Physiology, Anatomie u. Physiologie, Cardiovascular Disease