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Zusatztext "The book has a good plan and the authors have delivered on their assignments! With this one resource the reader can quickly obtain a current snapshot of the increasing use of capillary electrophoretic methods for the separation of the enantiomers of pharmaceutical compounds as well as the research that is currently underway to expand these methods."-Chromatographia! JAN 2011! 73:197-198"?this book provides a thorough introduction to the fundamental reaction classes in organometallic chemistry and a systematic survey of important catalytic methods. Organic chemists with little or no formal training in transition-metal chemistry often find themselves using transition-metal reagents or catalysts! and such individuals will find this to be a particularly useful resource. Meanwhile! experienced researchers and others with a strong background in the field will appreciate the extensive compilation of leading references to primary journal and review articles! which are cited liberally throughout the volume. The logical and systematic presentation of content in the book is well suited to meet the needs of students and researchers alike ? This book is destined to be the go-to resource for the field of transition-metal organometallic chemistry for many years to come. It will undoubtedly find a place on the bookshelf of virtually every organic and inorganic chemist! alongside classics like March's Advanced Organic Chemistry and Cotton and Wilkinson's Adlmnced Inorganic Chemistry."-Shannon S. Stahl! Univeristy of Wisconsin-Madison! Journal of the American Chemical Society! Vol. 132 Issues 21-24! 2010 Informationen zum Autor Ann Van Eeckhaut is a postdoctoral researcher in the Department of Pharmaceutical Chemistry and Drug Analysis in the School of Pharmacy at the Vrije Universiteit Brussel in Belgium. Yvette Michotte is the head of the Department of Pharmaceutical Chemistry and Drug Analysis in the School of Pharmacy at the Vrije Universiteit Brussel in Belgium. Klappentext Researchers find that capillary electrophoresis is an attractive tool for chiral separations! and since the 1980s! new technologies have allowed it to become a standard part of the chemists toolkit. This book provides a general overview of the principles of chiral separations by capillary electrophoresis and of the different chiral selectors available. In addition! pharmaceutical and biomedical applications and newer techniques such as capillary electrophoresis coupled to mass spectrometry and microchip technology are also covered. In two chapters the possibilities of capillary electrochromatography are exhibited! including the different chiral columns available. as well as some recent pharmaceutical and biomedical applications.. Zusammenfassung Provides a comprehensive overview of the principles of chiral separation by capillary electrophoresis and the different chiral selectors available. This book reviews pharmaceutical and biomedical applications and explores novel techniques, such as capillary electrophoresis coupled to mass spectrometry and microchip technology. Inhaltsverzeichnis Pharmacological Importance of Chiral Separations. Principles of Chiral Separations by Free-Solution Electrophoresis. Cyclodextrin-Mediated Chiral Separations. Factors Influencing Cyclodextrin-Mediated Chiral Separations. Macrocyclic Antibiotics as Chiral Selectors. Chiral Separations Using Proteins and Peptides as Chiral Selectors. Chiral Ligand Exchange Capillary Electrophoresis. Chiral Separations by Micellar Electrokinetic Chromatography. Chiral Microemulsion Electrokinetic Chromatography. Chiral Separations in Nonaqueous Media. Quantitative Analysis in Pharmaceutical Analysis. Analysis of Chiral Drugs in Body Fluids. Chiral Capillary Electrophoresis-Mass Spectrometry. Enantioseparations by Capillary Electrochromatography. Recent Application...
