Read more
Informationen zum Autor David Proud , Professor and Head, Department of Physiology & Biophysics, University of Calgary, Canada. Klappentext The past two decades have seen extraordinary advances in our understanding of the role of the pulmonary epithelium in airway health and disease. Our understanding of epithelial biology has expanded exponentially in the past decade.This book provides a unique comprehensive description of the structure of the epithelium, its damage by various agents and the mechanism of epithelial repair. In addition, it's detailed coverage includes not only the multiple ways in which the epithelium contributes to host defence, but also the nature and functional consequences of the interactions of inhaled pathogens, including viruses, bacteria, allergens and pollutants. the role of the epithelium in regulating airway inflammation and structure is also discussed, as is the role of the epithelium as a target for inhaled medications and as a route for novel drug delivery.Containing chapters on multiple aspects of epithelial function in health and disease, each one is written by a leader in the field. This is essential reading for pulmonary researchers and physicians requiring detailed advanced understanding of the epithelium as well as those working in allergy, biomedical and pharmaceutical research. Zusammenfassung "This is essential reading for everyone who would like to update their knowledge of the pulmonary epithelium. It offers a comparison between laboratory animal models and human lungs, highlighting the differences and the similarities between the two, which will be particularly useful to researchers. Inhaltsverzeichnis Preface. List of Contributors. 1. Pulmonary Epithelium: Cell Types and Functions (Mary Mann-Jong Chang, Laura Shih and Reen Wu). 1.1 Introduction. 1.2 Epithelial cell types and functions in the cartilaginous proximal airway region. 1.3 Epithelial cell types and functions of the non-cartilaginous distal bronchioles. 1.4 Epithelial cell types and functions of the gas exchange region. 1.5 Circulating stem cells and applications in lung regenerative medicine. 1.6 Stem cell therapy: embryonic or adult? 1.7 Conclusion. 2. Epithelial Adhesive Structures and Adhesion Molecule Expression (George Su and Dean Sheppard). 2.1 Introduction. 2.2 Cell-cell adhesive structures. 2.3 Cell-substratum adhesion. 2.4 Conclusion. 3. The Epithelium as a Target (Louise E. Donnelly). 3.1 Introduction. 3.2 Asthma. 3.3 Alteration in epithelial cell type distribution. 3.4 Overview of epithelial damage in asthma. 3.5 Chronic obstructive pulmonary disease. 3.6 Effect of cigarette smoke. 3.7 Other causative factors. 3.8 Alveolar epithelial cell apoptosis - emphysema. 3.9 Overview of epithelial damage in COPD. 3.10 Damage to the epithelium in other diseases. 3.11 Conclusions. 4. Epithelial Repair and Function (Carl G. A. Persson, Morgan Andersson and Lena Uller). 4.1 Brief introduction to epithelial shedding-repair and associated functions in health and disease. 4.2 Repair following shedding of single columnar epithelial cells and following shedding of clusters of columnar cells. 4.3 Epithelial denudation. 4.4 Pharmacology of epithelial repair. 4.5 Epithelial shedding-restitution as a causative process in airway inflammation and remodelling. 5. Integration of Epithelial Ion Transport Activities into Airway Surface Liquid Volume and Ion Composition Regulation (Mark T. Clunes, Peter F. Bove and Richard C. Boucher). 5.1 Introduction: the role of fluid in airway/alveolar physiology. 5.2 Model of ion and solute transport through airway epithelia. 5.3 Airway histology. 5....
