Reelin Glycoprotein - Structure, Biology and Roles in Health and Disease

Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. Reelin mutations or deficiency of the protein product could cause abnormal cortical development and reelin signaling impairment in brain. Reelin abnormalities in several neurospychiatric disorders, such as autism, schizophrenia, mood disorders and lissencephaly, may provide mechanistic explanations for etiologies of these disorders. There is also emerging data indicating the feasibility of using various medications (valproic acid, olanzapine) to increase mRNA/protein levels for reelin and/or gene therapy to prevent or treat reelin deficiencies observed in the above-mentioned disorders.
This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism.

List of contents

The Reelin Gene and Its Functions in Brain Development.- Apolipoprotein E Receptor 2 and Very-Low-Density Lipoprotein Receptor: An Overview.- Chemistry of Reelin.- The C-Terminal Region of Reelin: Structure and Function.- Crystal Structure of Reelin Repeats.- Comparative Anatomy and Evolutionary Roles of Reelin.- Reelin/Dab1 Signaling in the Developing Cerebral Cortex.- Ultrastructural Localization of Reelin.- Reelin and Cyclin-Dependent Kinase 5.- Reelin and the Cerebellum.- Reelin and Radial Glial Cells.- Reelin and Cognition.- Protein Kinases and Signaling Pathways that Are Activated by Reelin.- The Relationship of Oxytocin and Reelin in the Brain.- Reelin and Thyroid Hormone.- A Tale of Two Genes: Reelin and BDNF.- Reelin, Liver, and Lymphatics.- Reelin and Cajal-Retzius Cells.- Reelin and Odontogenesis.- Homozygous and Heterozygous Reeler Mouse Mutants.- Reelin and Lissencephaly.- The Role of Reelin in Etiology and Treatment of Psychiatric Disorders.- Reelin Downregulation as a Prospective Treatment Target for GABAergic Dysfunction in Schizophrenia.- Epigenetic Modulation of Reelin Function in Schizophrenia and Bipolar Disorder.- Reelin Gene Polymorphisms in Autistic Disorder.- Alzheimer's Disease and Reelin.- Reelin and Stroke.- Reelin and Pancreatic Cancer.

Summary

Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. Reelin mutations or deficiency of the protein product could cause abnormal cortical development and reelin signaling impairment in brain. Reelin abnormalities in several neurospychiatric disorders, such as autism, schizophrenia, mood disorders and lissencephaly, may provide mechanistic explanations for etiologies of these disorders. There is also emerging data indicating the feasibility of using various medications (valproic acid, olanzapine) to increase mRNA/protein levels for reelin and/or gene therapy to prevent or treat reelin deficiencies observed in the above-mentioned disorders.
This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism.

Additional text

From the reviews:
"The glycoprotein reelin, involved in a multitude of important neurobiological processes including embryogenesis and brain development, is the focus of this informative and interesting book. … The intended audience includes researchers in the field and clinicians. Clinicians who are interested in understanding the importance of epigenetic factors involved in neuropsychiatric disorders would be find this book helpful. … This is an excellent summary of the current state of research findings on this putatively important glycoprotein." (Michael J. Schrift, Doody’s Review Service, July, 2009)

“The whole book is dedicated just to one biopolymer, reelin, which is a major secretory glycoprotein with biological activity in various processes of our body. … The book consists of 28 chapters presented by international group of experts. … book will be very useful as foundation for analysis of this emerging novel glycoprotein for biochemists, molecular biologists, neuroscientists, and clinicians specialized in psychiatric disorders.” (G. Ya. Wiederschain, Biochemistry, Vol. 75 (5), 2010)

Report

From the reviews:
"The glycoprotein reelin, involved in a multitude of important neurobiological processes including embryogenesis and brain development, is the focus of this informative and interesting book. ... The intended audience includes researchers in the field and clinicians. Clinicians who are interested in understanding the importance of epigenetic factors involved in neuropsychiatric disorders would be find this book helpful. ... This is an excellent summary of the current state of research findings on this putatively important glycoprotein." (Michael J. Schrift, Doody's Review Service, July, 2009)
"The whole book is dedicated just to one biopolymer, reelin, which is a major secretory glycoprotein with biological activity in various processes of our body. ... The book consists of 28 chapters presented by international group of experts. ... book will be very useful as foundation for analysis of this emerging novel glycoprotein for biochemists, molecular biologists, neuroscientists, and clinicians specialized in psychiatric disorders." (G. Ya. Wiederschain, Biochemistry, Vol. 75 (5), 2010)

Product details

• Assisted by: S. H. Fatemi (Editor), S. Hossein Fatemi (Editor), S.H. Fatemi (Editor), H Fatemi (Editor), S H Fatemi (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 23.02.2011
• EAN: 9780387767604
• ISBN: 978-0-387-76760-4
• No. of pages: 443
• Dimensions: 155 mm x 239 mm x 32 mm
• Weight: 878 g
• Illustrations: XXIII, 443 p.
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; Protein, B, Brain, Cortex, Stroke, Neuroscience, Autism, Cognition, Neurosciences, schizophrenia, Biomedical and Life Sciences, cerebral cortex, receptor