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Informationen zum Autor Alexei Verkhratsky is Professor of Neurophysiology and Chairman of the Division of Neuroscience at the University of Manchester, UK Arthur Butt is Professor of Cellular Neurophysiology, Department of Pharmacy and Biomedical Sciences, University of Portsmouth, UK. Klappentext Glial cells are the most numerous cells in the human brain but for many years have attracted little scientific attention. Neurophysiologists concentrated their research efforts instead on neurones and neuronal networks, because it was thought that they were the key elements responsible for higher brain function. Recent advances, however, indicate this isn't exactly the case. Not only are astroglial cells the stem elements from which neurones are born, but they also control the development, functional activity and death of neuronal circuits. These ground-breaking developments have revolutionized our understanding of the human brain and the complex interrelationship of glial and neuronal networks in health and disease.Features of this book:* an accessible introduction to glial neurobiology including an overview of glial cell function and its active role in neural processes, brain fusion and nervous system pathology* an exploration of all the major types of glial cells including: the astrocytes, oligodendrocytes and microglia of the CNS and Schwann cells of the peripheral nervous system; the book also presents a broad overview of glial receptors and ion channels* an investigation into the role of glial cells in various types of brain diseases including stroke, neurodegenerative diseases such as Alzheimer's, Parkinson's and Alexander's disease, brain oedema, multiple sclerosis and many more* a wealth of illustrations, including unique images from the authors' own libraries of image,s describing the main features of glial cellsWritten by two leading experts in the field, Glial Neurobiology provides a concise, authoritative introduction to glial physiology and pathology for undergraduate/postgraduate neuroscience, biomedical, medical, pharmacy, pharmacology,k and neurology, neurosurgery and physiology students. It will also appeal to researchers in neuroscience, physiology, pharmacology and pharmaceutics. Zusammenfassung AT LAST - A comprehensive, accessible textbook on glial neurobiology! Authored by leading experts in the field, Glial Neurobiology provides a concise, thorough and up-do-date overview of glial cells function, the role of glial cells in various neural processes and their involvement in nervous system pathology. Inhaltsverzeichnis Preface. List of abbreviations. PART I Physiology of Glia. 1 Introduction to Glia. 1.1 Founders of glial research: from Gabriel Valentin to Karl-Ludwig Schleich. 1.2 Beginning of the modern era. 1.3 Changing concepts: Glia express molecules of excitation. 1.4 Glia and neurones in dialogue. 2 General Overview of Signalling in the Nervous System. 2.1 Intercellular signalling: Wiring and volume modes of transmission. 2.2 Intracellular signalling. 3 Morphology of Glial Cells. 3.1 Astrocytes. 3.2 Oligodendrocytes. 3.3 NG2 expressing glia. 3.4 Schwann cells. 3.5 Microglia. 4 Glial Development. 4.1 Phylogeny of glia and evolutionary specificity of glial cells in human brain. 4.2 Macroglial cells. 4.3 Astroglial cells are brain stem cells. 4.4 Schwann cell lineage. 4.5 Microglial cell lineage. 5 General Physiology of Glial Cells. 5.1 Membrane potential and ion distribution. 5.2 Ion channels. 5.3 Receptors to neurotransmitters and neuromodulators. 5.4 Glial syncytium - gap junctions. 5.5 Glial calcium signalling. 5.6 Neurotransmitter release from astroglial cells. 5.7 Glial neurotr...
