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Informationen zum Autor James Devillers Zusammenfassung Presents an overview of approaches for modeling the endocrine activity of chemicals and the adverse effects they may induce on environmental and human health. This work focuses on chemicals accidentally released into the environment and also on the design, in agro-chemistry, of chemicals acting on the endocrine system of insects to control them. Inhaltsverzeichnis In Silico Methods for Modeling Endocrine Disruption! J. DevillersMechanisms of Endocrine Disruptions! A Tentative Overview! J.M. Porcher! J. Devillers! and N. Marchand-GenestePopulation Dynamics Modeling: A Tool For Environmental Risk Assessment of Endocrine Disrupting Chemicals! A.R. Brown! P.F. Robinson! A.M. Riddle! and G.H. PanterApplication of Pharmacokinetic Modeling to Understand the Mechanism of Action of Endocrine Disrupting Chemicals! J. DevillersComparative Modeling Review of Nuclear Hormone Receptor Superfamily! N. Marchand-Geneste and J. DevillersThe FDA's Endocrine Disruptor Knowledge Base (EDKB): Lessons Learned in QSAR Modeling and Applications! H. Fang! R. Perkins! L. Shi! D.M. Sheehan! and W. TongA Structure-Activity Relationship (SAR) Analysis for the Identification of Environmental Estrogens: The Categorical-SAR (cat-SAR) Approach! A.R. Cunningham! D.M. Consoer! S.A. Iype! and S.L. CunninghamKohonen and Counterpropagation Neural Networks Employed for Modeling Endocrine Disruptors! M. Novic and M. VrackoQuantitative Spectrometric Data-Activity Relationships (QSDAR) Models of Endocrine Disruptor Binding Activities! R.D. Beger! D.A. Buzatu! and J.G. WilkesMechanism-Based Modeling of Estrogen Receptor Binding Affinity: A COREPA Implementation! O. Mekenyan and R. SerafimovaMolecular Field Analysis Methods for Modeling Endocrine Disruptors! J.P. Doucet and A. PanayeStructure-Activity Modeling of a Diverse Set of Androgen Receptor Ligands! J. Devillers! J.P. Doucet! A. Panaye! N. Marchand-Geneste! and J.M. PorcherSAR and QSAR Analyses of Substituted Dibenzoylhydrazines for Their Mode of Action as Ecdysone Agonists! T. Fujita and Y. Nakagawae-Endocrine Disrupting Chemical Databases for Deriving SAR and QSAR Models! N. Marchand-Geneste! J. Devillers! J.C. Doré! and J.M. Porcher ...
