Antisense Drug Technology - Principles, Strategies, and Applications, Second Edition

Zusatztext This book gives a nearly complete overview of the current state-of-the-art oligonucleotide drugs. ? provides valuable insights into the great opportunities that are presented by this technology.-Dr. Kees Fluiter! The University of Amsterdam! in ChemMedChem! Vol. 4! 2009This edition is a cutting edge document including up-to-date cited references and a variety of compelling clinical case studies! and it of course retains the superb basic principles and background to antisense drug technologies featured in the first edition.-Gary Evans! Industrial Research Ltd.! in Journal of Medicinal Chemistry! 2008! Vol. 51! No. 5 Informationen zum Autor Stanley T. Crooke Klappentext Divided into five parts! this book offers an introduction to the mechanism of antisense drug action including the RNase H mechanism! small RNA silencing pathways! and the potential therapeutics of splice switching oligonucleotides. Zusammenfassung Divided into five parts, this book offers an introduction to the mechanism of antisense drug action including the RNase H mechanism, small RNA silencing pathways, and the potential therapeutics of splice switching oligonucleotides. Inhaltsverzeichnis Introduction, The Basics of Oligonucleotide-Based Therapeutics, Hybridization-Based Drugs: Basic Properties 2 _ - O -Methoxyethyl Oligonucleotides, Hybridization-Based Drugs: Basic Properties Duplex RNA Drugs, Other Chemical Classes of Drugs, Therapeutic Applications, Index

Product details

• Authors: Stanley T. Crooke, Stanley T. (ISIS Pharmaceuticals Inc. Crooke, CROOKE STANLEY T
• Assisted by: Stanley T. Crooke (Editor), Crooke Stanley T. (Editor)
• Publisher: Taylor & Francis Ltd.
• Languages: English
• Product format: Hardback
• Released: 25.07.2007
• EAN: 9780849387968
• ISBN: 978-0-8493-8796-8
• No. of pages: 856
• Subjects: Natural sciences, medicine, IT, technology > Technology > Chemical engineering; Science: general issues, MEDICAL / Pharmacy, SCIENCE / Chemistry / General, MEDICAL / Biotechnology, chemistry, Pharmacology, Pharmaceutical chemistry and technology