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Informationen zum Autor Ralph Marvin Steinman was a Canadian physician and medical researcher at Rockefeller University, who in 1973 discovered and named dendritic cells while working as a postdoctoral fellow in the laboratory of Zanvil A. Cohn, also at Rockefeller University. Klappentext Biomedical research on human subjects is notoriously difficult because of the difficulties in controlling the variables, locating a large enough sample size, and managing the ethical issues that have to be considered for every experiment. This volume contains contributions from scientists who have received grants from the Dana Foundation, and their work in the complex and diverse field of human immunology is notable for both its breadth and its depth. Patient-based research in the areas of cancer, infectious disease, allergy, inflammation, and autoimmunity are summarized. It is through clinical studies that findings in animal models make their way into the arsenal of treatments available for human patients, and this volume demonstrates the progress of translational research in human immunology. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member. Zusammenfassung Biomedical research on human subjects is notoriously difficult because of the difficulties in controlling the variables! locating a large enough sample size! and managing the ethical issues that have to be considered for every experiment. Inhaltsverzeichnis Foreword: Ralph M. Steinman. Part I: Cancer:. 1. B-Cell Chronic Lymphocytic Leukemia, a Clonal Disease of B Lymphocytes with Receptors that Vary in Specificity for (Auto)antigens: Nicholas Chiorazzi, Katerina Hatzi, and Emilia Albesiano. 2. Harnessing the Immune System Against Human Glioma: Kavita M. Dhodapkar, Devi Banerjee, and Ralph M. Steinman. 3. Immune Response to Premalignancy: Insights from Patients with Monoclonal Gammopathy: Madhav V. Dhodapkar. 4. Evaluation of Anticyclin B1 Serum Antibody as a Diagnostic and Prognostic Biomarker for Lung Cancer: Ann Marie Egloff, Joel Weissfeld, Stephanie R. Land, and Olivera J. Finn. 5. Manipulating the Local Tumor Microenvironment with Poxviruses Expressing Costimulatory Molecules: Howard L. Kaufman. 6. CD154 Gene Therapy for Human B-Cell Malignancies: Davorka Messmer and Thomas J. Kipps. 7. The Challenge of Analyzing the Proteome in Humans with Autoimmune Diseases: Steven M. Chan and Paul J. Utz. Part II: Infection:. 8. The Immune Response to BCG Vaccination of Newborns: Willem A. Hanekom. 9. Regulation of Acquired Immunity by T-Cell/Dendritic-Cell Interactions: Niraj Shrestha, James A. Ida, A. Steven Lubinski, Maria Pallin, Gilla Kaplan, and Patrick A.J. Haslett. 10. TLR1 and TLR6 Polymorphisms Are Associated with Susceptibility to Invasive Aspergillosis after Allogeneic Stem Cell Transplantation: Sandra Kesh, Nana Yaa Mensah, Paolo Peterlongo, Dana Jaffe, Katharine Hsu, Marcel Van Den Brink, Richard O'reilly, Eric Pamer, Jaya Satagopan, and G. A. Papanicolaou. 11. T-Cell Immunotherapy for Adenoviral Infections of Stem-Cell Transplant Recipients: A. M. Leen, G. D. Myers, C. M. Bollard, M. H. Huls, U. Sili, A. P. Gee, H. E. Heslop, and C. M. Rooney. Part III: Autoimmunity:. 12. Human B Cell Tolerance and Its Failure in Rheumatoid Arthritis: Jonathan Samuels, Yen-Shing Ng, Claire Coupillaud, Dan...
