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This volume records the proceedings of the Workshop on Advanced Meth ods of Pharmacokinetic and Pharmacodynamic Systems Analysis, organized by the Biomedical Simulations Resource in May 1990. The meeting brought together over 120 investigators from a number of disciplines, including clinical pharmacology, clinical pharmacy, pharmaceutical science, biomathematics, statistics and biomed ical engineering with the purpose of providing a high-level forum to facilitate the exchange of ideas between basic and clinical research scientists, experimentalists and modelers working on problems in pharmacokinetics and pharmacodynamics. It has been my experience that in many areas of biomedical research, when a meeting of this type is held, the general attitude of those experimentalists willing to attend is one of extreme skepticism: as a group they feel that mathematical modeling has little to offer them in furthering their understanding of the particular biological processes they are studying. This is certainly not the prevailing view when the topic is pharmacokinetics and drug response. Quite the contrary, the use of mathemati cal modeling and associated data analysis and computational methods has been a central feature of pharmacokinetics almost from its beginnings. In fact, the field has borrowed techniques of modeling from other disciplines including applied math ematics, statistics and engineering, in an effort to better describe and understand the processes of drug disposition and drug response.
List of contents
Pharmacokinetics: Physiological and Biochemical Basis.- Predicting Oral Drug Absorption in Humans: A Macroscopic Mass Balance Approach for Passive and Carrier-Mediated Compounds.- Pharmacokinetics of Linear Reversible Metabolic Systems.- Pharmacokinetic Models for Anticancer and Antiviral Drugs following Administration as Novel Drug Delivery Systems.- The Significance of Marked "Universal" Dependence of Drug Concentration on Blood Sampling Site in Pharmacokinetics and Pharmacodynamics.- Pharmacodynamics: Measurements and Models.- Physiological Alternatives to the Effect Compartment Model.- Pharmacokinetics/Dynamics of Corticosteroids.- Variability in Human Cardiovascular Pharmacodynamics.- Pharmacodynamic Modeling of Thiopental Depth of Anesthesia.- Pharmacometrics: Modeling, Estimation and Control.- Residence Time Distributions in Pharmacokinetics: Behavioral and Structural Models.- Pharmacokinetic Parameter Estimation with Stochastic Dynamic Models.- Relationships between Intra- or Interindividual Variability and Biological Covariates: Application to Zidovudine Pharmacokinetics.- On the Single-Point, Single-Dose Problem.- Application of Stochastic Control Theory to Optimal Design of Dosage Regimens.- Pharmacotherapeutics: Measurement, Control and Delivery.- Development of a Fiber Optic Sensor for Detection of General Anesthetics and Other Small Organic Molecules.- A Bayesian Kinetic Control Strategy for Cyclosporin in Renal Transplantation.- Targeted Systemic Exposure for Pediatric Cancer Therapy.- Targeting the Effect Site With a Computer Controlled Infusion Pump.- Contributors.- Participants.
Summary
Proceedings of the 1990 Biomedical Simulations Resource Workshop, held in Marina del Rey, California, May 18-19, 1990
