Polymorphism in Pharmaceutical Solids

Informationen zum Autor Brittain, Harry G. Zusammenfassung Polymorphism in Pharmaceutical Solids Inhaltsverzeichnis 1. Thermodynamic and Theoretical Issues. 1.1. Theory and Origin of Polymorphism. 1.2. Application of the Phase Rule. 1.3. Computational Methodologies. 2. Preparative Methods for Polymorphs and Solvatomorphs. 2.1. Classical Methods of Preparation. 2.2. High-Throughput Screening Methods. 3. Structural Properties of Polymorphs and Solvatomorphs. 3.1. Polymorphic Systems. 3.2. Solvatomorphic Systems. 3.3. Pharmaceutical Cocrystals. 4. Characterization Methods for Polymorphs and Solvatomorphs. 4.1. Thermal and Crystallographic. 4.2. Vibrational Spectroscopy. 4.3. Solid-State NMR. 4.4. Solubility and Dissolution Rate. 5. Interconversion of Polymorphs and Solvatomorphs. 5.1. Thermally-Induced and Solution-Mediated Phase Transformations. 5.2. Effects of Secondary Processing. 5.3. Structural Aspects of Molecular Dissymmetry. 5.4. Amorphous Solids.

List of contents

1. Thermodynamic and Theoretical Issues. 1.1. Theory and Origin of Polymorphism. 1.2. Application of the Phase Rule. 1.3. Computational Methodologies. 2. Preparative Methods for Polymorphs and Solvatomorphs. 2.1. Classical Methods of Preparation. 2.2. High-Throughput Screening Methods. 3. Structural Properties of Polymorphs and Solvatomorphs. 3.1. Polymorphic Systems. 3.2. Solvatomorphic Systems. 3.3. Pharmaceutical Cocrystals. 4. Characterization Methods for Polymorphs and Solvatomorphs. 4.1. Thermal and Crystallographic. 4.2. Vibrational Spectroscopy. 4.3. Solid-State NMR. 4.4. Solubility and Dissolution Rate. 5. Interconversion of Polymorphs and Solvatomorphs. 5.1. Thermally-Induced and Solution-Mediated Phase Transformations. 5.2. Effects of Secondary Processing. 5.3. Structural Aspects of Molecular Dissymmetry. 5.4. Amorphous Solids.

Product details

• Authors: Harry G. Brittain, Harry G. (Center for Pharmaceutical Phys Brittain, BRITTAIN HARRY G
• Assisted by: Harry G. Brittain (Editor), Harry G. (Center for Pharmaceutical Physics Brittain (Editor), Brittain Harry G. (Editor)
• Publisher: Taylor & Francis Ltd.
• Languages: English
• Product format: Hardback
• Released: 27.07.2009
• EAN: 9781420073218
• ISBN: 978-1-4200-7321-8
• No. of pages: 652
• Series: Drugs and the Pharmaceutical Sciences; Drugs and the Pharmaceutical Sciences
• Subjects: Natural sciences, medicine, IT, technology > Medicine > General; Medicine: general issues, SCIENCE / Chemistry / General, MEDICAL / Pharmacology, Biology, life sciences, Engineering: general, Pharmaceutical technology, Manufacturing industries, Pharmaceutical industries, Pharmaceutical chemistry and technology