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The field of angiogenesis is one of the most exciting fields in
contemporary biomedical research. Angiogenesis in the healthy adult is
primarily associated with pathological conditions such as tumor
growth, inflammation, ischemia, and retinopathies. Physiological
angiogenesis in the healthy adult is restricted to the organs of the
female reproductive system where it occurs cyclically as well as
during pregnancy. The importance of vascular morphogenetic events in
the female reproductive system is increasingly being recognized. For
example, it has a vital role in normal ovarian function, endometriosis
and placental function as well as being important in reproductive
tumors of the mammary gland, ovary and uterus. The insights gained
from studying this system have a more general interest too since they
help shed light on the fundamental characteristics and components
involved in the formation of the vascular system and blood vessels
during development, and during tumorigenesis.
This is the first book that reviews and presents recent advances in
the emerging field of reproductive vascular biology. It is divided
into four parts reflecting the four female reproductive organs
(breast, ovary, uterus, and placenta) and the authors cover both the
basic biological processes involved and also stress their clinical
significance.
The book will interest vascular and reproductive biologists as well as
cell and developmental biologists interested in angiogenesis and
vasculogenesis.
List of contents
Part 1: Vascular Morphogenesis in the Mammary Gland// Chapter
1:Vascular morphogenesis in the mammary gland - Introduction and
overview. M. Luisa Iruela-Arispe, Maria Asuncion Ortega, Sarah
Oikemus, and Michael S. Pepper Chapter 2: Growth factor regulation of
physiological angiogenesis in the mammary gland. Anne Saaristo,
Marika J. Karkkainen, Kari Alitalo, Roberto Montesano, Luisa Iruela-
Arispe, and Michael S. Pepper Chapter 3: The role of angiogenesis in
breast cancer progression. Sandra W. McLeskey and Robert B. Dickson
Chapter 4: Angiogenesis in mammary tumors: Quantitation and relation
to prognosis. Stephen B. Fox Chapter 5: Oncogenes, anti-oncogenes
and genetic regulators of vascular development. Timothy F. Lane and
Alicia Collado-Hidalgo// Part 2: Vascular Morphogenesis in the
Ovary//Chapter 6: Vascular morphogenesis in the ovary - Introduction
and overview. Hellmut G. Augustin Chapter 7: Growth factors during
ovarian angiogenesis. Anna T. Grazul-Bilska, Dale A. Redmer, and
Lawrence P. Reynolds Chapter 8: Vascular endothelial cell growth
factor: A key regulator of physiological angiogenesis. Napoleone
Ferrara Chapter 9: Hormonal regulation of gonadal angiogenesis. H.
Summary
The overall scope of this new series will be to evolve an understanding of the genetic basis of (1) how early mesoderm commits to cells of a heart lineage that progressively and irreversibly assemble into a segmented, primary heart tube that can be remodeled into a four-chambered organ, and (2) how blood vessels are derived and assembled both in the heart and in the body. Our central aim is to establish a four-dimensional, spatiotemporal foundation for the heart and blood vessels that can be genetically dissected for function and mechanism. Since Robert DeHaan's seminal chapter "Morphogenesis of the Vertebrate Heart" published in Organogenesis (Holt Rinehart & Winston, NY) in 1965, there have been surprisingly few books devoted to the subject of cardiovascular morpho genesis, despite the enormous growth of interest that occurred nationally and inter nationally. Most writings on the subject have been scholarly compilations of the proceedings of major national or international symposia or multi authored volumes, without a specific theme. What is missing are the unifying concepts that can often make sense out of a burgeoning database of facts. The Editorial Board of this new series believes the time has come for a book series dedicated to cardiovascular mor not only as an important archival and didactic reference phogenesis that will serve source for those who have recently come into the field but also as a guide to the evo lution of a field that is clearly coming of age.
