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Recent experimental evidence has made it increasingly clear In particular, this volume reviews the discrete steps involved that the properties of invasive, malignant cells during tumor in metastatic invasion: the interaction of invasive tumor cells development substantially impact on the host. This is under with extracellular matrices, the basement membrane, attach scored by a variety of biochemical properties of tumor cells ment to extracellular matrices, local proteolytic degradation during their differentiation and metastatic dissemination. of matrices, and the locomotion of invasive tumor cells These properties can be analyzed at different stages of tumor through such areas of localized degradation. The critical growth and progression and this volume explores the role of the cell surface in secondary tumor formation is characteristics of primary tumors as well as the shared reviewed as are important advances in the molecular biology characteristics of both primary and secondary tumors. of metastasis initiation and maintenance. Recent advances The primary tumor comes into existence following in the role of DNA methylation in the generation of tumor preneoplastic biochemical and cellular events that ultimate cell heterogeneity and tumor progression are also critically ly result in malignant transformation. Various aspects of summarized. Chapters in this volume also review molecular metabolism, predetermined by nutritional status, often play aspects of metastatic progression, and the use of the tech a basic role. Obesity, for example, is cancer-promoting. Cell nologies of DNA transfection and somatic cell fusion in the surface carbohydrates, cytoskeletal proteins, glycoproteins, exploration of molecular aspects of metastatic progression.
List of contents
A. Aspects of the primary tumor.- 1. Stroma, generally a non-neoplastic structure of the tumor.- 2. Malignant transformation.- 3. Metabolic changes in malignancy.- 4. Ion deregulation, cell injury, and tumor promotion.- 5. Multiple primary neoplasms: role of autopsy. Selected sites with emphasis on Japan.- 6. Multiple primary neoplasms.- B. Shared aspects of primary and secondary tumors.- 7. Mechanisms of cancer invasion and metastases.- 8. Extracellular matrix and its enzymatic degradation in tumor invasion.- 9. Cell surface and secondary tumor formation.- 10. DNA transfection, genetic instability, and metastasis.- 11. The contribution of DNA methylation to the generation of tumor cell heterogeneity, tumor progression and metastasis.- 12. Neoplastic progression by somatic cell fusion.- 13. Cell junctional alterations in cancer.- 14. Cytogenetic studies in neoplasia (human and animal): Implications, prognosis, and treatment.- 15. Cancer cachexia.- 16. Paraneoplastic syndromes.- Index of subjects.
Report
`... the present volume offers a wealth of detailed information of great interest to pathologists to be used in basic research as well as in his clinical activities.'
