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The application of hemodiafiltration has been restricted until recently, when a broader clinical application has been made possible due to evidence from large studies and clinical investigations. This book provides an updated review of the evolution, advances and recent results achieved by hemodiafiltration in the clinical arena. The first part is devoted to historical notes and an outline of the evolution of different forms of hemodiafiltration, made possible by technological developments in the fields of membranes, machines and fluids. The next section describes the theoretical rationale for hemodiafiltration, providing a detailed analysis of the involved mass separation processes, the hydraulic properties of the dialyzers, fluid mechanics and crossfiltration in hollow fiber hemodialyzers. An outline of different hemodiafiltration techniques, also reporting peculiar transport mechanisms and related technology, is given next, and a section on the clinical effects of hemodiafiltration concludes this book. Including different technologies, the publication offers a complete overview of the technical and clinical possibilities provided by hemodiafiltration in its widest concept, ranging from the molecular basis to the most practical application. It will be a valuable tool for the implementation of hemodiafiltration in daily practice aimed at beginners and experts, scientists and physicians, students and senior faculty members alike.
List of contents
Preface: Ronco, C.; Canaud, B.; Aljama, P.; History and Evolution; The Birth of Hemodiafiltration: Henderson, L.W.; Evolution of Hemodiafiltration: Ronco, C.; Basic Principles; Solute Removal by Hollow-Fiber Dialyzers: Clark, W.R.; Rocha, E.; Ronco, C.; Fluid Mechanics and Crossfiltration in Hollow-Fiber Hemodialyzers: Ronco, C.; Mechanisms of Solute and Fluid Removal in Hemodiafiltration: Yamashita, A.C.; Membranes and Hardware for Hemodiafiltration; Membranes and Filters for Haemodiafiltration: Hoenich, N.A.; Technical Aspects of Online Hemodiafiltration: Polaschegg, H.-D.; Roy, T.; Technical Aspects and Fluids in Hemodiafiltration; Quality of Water, Dialysate and Infusate: Cappelli, G.; Ricardi, M.; Bonucchi, D.; De Amicis, S.; Fluids in Bags for Hemodiafiltration: Ledebo, I.; Hemodiafiltration with Endogenous Reinfusion: Wratten, M.L.; Ghezzi, P.M.; Hemodiafiltration Techniques; Low- (Classical) and High-Efficiency Haemodiafiltration: Wizemann, V.; Online Hemodiafiltration: Technical Options and Best Clinical Practices: Canaud, B.; Mixed-Dilution Hemodiafiltration: Pedrini, L.A.; Zerbi, S.; Paired Hemodiafiltration: Pizzarelli, F.; Acetate-Free Biofiltration: Santoro, A.; Guarnieri, F.; Ferramosca, E.; Grandi, F.; Mid-Dilution: An Innovative High-Quality and Safe Haemodiafiltration Approach: Potier, J.; Double High-Flux Hemodiafiltration: von Albertini, B.; Push/Pull Hemodiafiltration: Shinzato, T.; Maeda, K.; Principles and Practice of Internal Hemodiafiltration: Fiore, G.B.; Ronco, C.; Clinical Aspects of Hemodiafiltration; Clinical Aspects of Haemodiafiltration: Locatelli, F.; Di Filippo, S.; Manzoni, C.; The Biological Response to Online Hemodiafiltration: Panichi, V.; Tetta, C.; Clearance of Beta-2-Microglobulin and Middle Molecules in Haemodiafiltration: Tattersall, J.; Inflammation and Hemodiafiltration: Ramirez, R.; Martin-Malo, A.; Aljama, P.; Effect of Online Hemodiafiltration on Morbidity and Mortality of Chronic Kidney Disease Patients: Canaud, B.; Optimizing the Prescription of Hemodiafiltration: Maduell, F.
