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Informationen zum Autor Desmond J. Brown is Professor of Chemistry at The Australian National University's Research School of Chemistry. Klappentext The Chemistry of Heterocyclic Compounds , since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects - properties, synthesis, reactions, physiological and industrial significance - of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists. Inhaltsverzeichnis Chapter I. Introduction to the Pyrimidines 1 1. History 1 2. Nomenclature 3 3. The Unique Basis of Pyrimidine Chemistry 5 4. General Summary of Pyrimidine Chemistry 9 5. Physical Properties of Pyrimidines 26 Chapter II. The Principal Synthetic Method 31 1. General Scope 31 2. Use of ß -Dialdehydes 32 3. Use of ß-Aldehydo Ketones 34 4. Use of ß Diketones 36 5. Use of ß-Aldehydo Esters 38 6. Use of ß-Keto Esters 48 7. Use of ß-Diesters (Malonic Esters) 51 8. Use of ß-Aldehydo Nitriles 59 9. Use of ß -Keto Nitriles 65 10. Use of ß -Ester Nitriles 11. Use of ß -Dinitriles (Malononitriles) Chapter III. Other Methods of Primary Synthesis 82 1. General Remarks 82 2. Syntheses Involving Preformed Amino-methylene Groups 82 3. Syntheses Involving an Aminomethylene Group Formed In Situ 90 4. Syntheses from Malondiamides and Malondiamidine 97 5. Other Syntheses of Pyrimidines 101 6. Formation of Pyrimidine Rmg in Fused Heterocycles 107 Chapter IV. Pyrimidine and Its C-Alkyl and C-Aryl Derivatives 116 1. Pyrimidine (Unsubstituted) 116 2. C-Alkyl- and C-Aryl-pyrimidines 119 Chapter V. Nitro-, Nitroso-, and AryIazo-pyrimidines 138 1. The Nitropyrimidines 138 2. Nitrosopyrimidines 146 3. The Arylazopyrimidines 152 Chapter VI. Halogenopyrimidines 162 1. The Preparation of 2 4. and 6-Halogenopyrimidines 162 2. The Preparation of 5-Halogenopyrimidines 168 3. The Preparation of Extranuclear Halogenopyrimidines 176 4. Properties of Halogenopyrimidines 181 5. Reactions of 2-, 4-, and 6-Halogenopyrimidines 183 6. Reactions of 5-Halogenopyrimidines 210 7. Reactions of Extranuclear Halogenopyrimidines 214 Chapter VII. Hydroxy- and Alkoxy-pyrimidines 227 1. Preparation of 2 4 and 6-Hydroxypyrimidines 227 2. Preparation of 5-Hydroxypyrimidines 237 3. Preparation of Extranuclear Hydroxypyrimidines 241 4. Preparation of Alkoxy- and Aryloxy-pyrimidines 245 5. Properties and Structure of Hydroxy- and Alkoxy-pyrimidines 249 6. Reactions of Hydroxypyrimidines 250 7. Reactions of AIkoxy- and Aryloxy-pyrimidines 254 8. Some Naturally Occurring Hydroxypyrimidines 256 9. The Alloxan Group of Pyrimidines 260 Chapter VIII. Sulphur-containing Pyrimidines 272 I. The Mercaptopyrimidines 272 2. The Thioethers: Alkylthio- and Arylthio-pyrimidines 286 3. DipyrimidinyI Disulphides and Sulphides 291 4. Pyrimidine Sulphonic Acids and Related Compounds 295 5. Alkylsulphonylpyrimidines 298 6. Thiouracil and Homologues 300 Chapter IX. The Aminopyrimidines 306 1. Preparation of 2-, 4-, and 6-Aminopyrimidines 306 2. Reparati...
