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Cancer stem cells werehave originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor, as they divide much more slowly and have very efficient drug- resistance mechanisms. Current treatments might largely spare cancer stem cells, thus leading to tumor recurrence and metastasis. The recent identification of growth and differentiation pathways responsible for cancer stem cell proliferation and survival will help in the discovery identification of novel therapeutic targets. Developing selective drugs against cancer stem cells offers great therapeutic opportunities but also provides for major challenges regarding preclinical models, therapeutic windows, and clinical study end points.
List of contents
Niche for Normal and Cancer Stem Cells.- c-Myc and Activated Ras During Skin Tumorigenesis: Cooperation at the Cancer Stem Cell Level?.- Wnt Signaling in Stem Cells and Lung Cancer.- Bone Morphogenetic Proteins Regulate Tumorigenicity in Human Glioblastoma Stem Cells.- Strategies to Induce Nuclear Reprogramming.- The Intestinal Stem Cell Niche Studied Through Conditional Transgenesis.- The Migrating Cancer Stem Cells Model - A Conceptual Explanation of Malignant Tumour Progression.- Bone Marrow Niche and Leukemia.- Breast Stem Cells and Cancer.- Prostate Cancer Stem Cells: A Target for New Therapies.- The Hedgehog Signaling Network, Mammary Stem Cells, and Breast Cancer: Connections and Controversies.- Strategies to Eliminate Cancer Stem Cells.- DNA Repair in Stem Cell Maintenance and Conversion to Cancer Stem Cells.- Tumorigenic Epithelial Stem Cells and Their Normal Counterparts.
Summary
Cancer stem cells werehave originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor, as they divide much more slowly and have very efficient drug- resistance mechanisms. Current treatments might largely spare cancer stem cells, thus leading to tumor recurrence and metastasis. The recent identification of growth and differentiation pathways responsible for cancer stem cell proliferation and survival will help in the discovery identification of novel therapeutic targets. Developing selective drugs against cancer stem cells offers great therapeutic opportunities but also provides for major challenges regarding preclinical models, therapeutic windows, and clinical study end points.
