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Informationen zum Autor Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School. Klappentext Advances in Immunology, a long established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Zusammenfassung Presents developments as well as comprehensive reviews in immunology. This title includes articles that addresses the range of topics that comprise immunology! including molecular and cellular activation mechanisms! phylogeny and molecular evolution! and clinical modalities. Inhaltsverzeichnis Fate Decisions Regulating Bone Marrow and Peripheral B Lymphocyte Development Tolerance and Autoimmunity: Lessons at the bed-side of Primary Immunodeficiencies B cell self-tolerance in humans Manipulation of regulatory T-cell number and function with CD28-specific monoclonal antibodies Osteoimmunology: a view from the bone Mast Cell Proteases...
List of contents
Fate Decisions Regulating Bone Marrow and Peripheral B Lymphocyte Development
Tolerance and Autoimmunity: Lessons at the bed-side of Primary Immunodeficiencies
B cell self-tolerance in humans
Manipulation of regulatory T-cell number and function with CD28-specific monoclonal antibodies
Osteoimmunology: a view from the bone
Mast Cell Proteases
