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Informationen zum Autor Mone Zaidi is the editor of Skeletal Development and Remodeling in Health, Disease and Aging, Volume 1068, published by Wiley. Klappentext Our understanding of how the skeleton is remodeled and repaired has been enormously expanded in the past decade. Using advanced molecular technologies including transgenesis, gene knockout, and gene array, we are gaining a better understanding of both the precise pathways through which osteoblasts lay down new bone and how osteoclasts remove old bone. These studies have not only helped us understand the basic biological properties of the skeleton and how it responds to hormonal, cytokine, and mechanical stimulation, but also, in some instances, clarified the source of pathophysiology. The eventual goal of such discoveries is to lay down a firm scientific foundation for the identification of novel cellular and molecular targets for future drug development. This volume presents the significant headway that scientists have made in this undertaking and the book is organized around four broad themes: skeletal development and repair, molecular endocrinology of bone, bone cell biology, and conservation of skeletal integrity. Also included are papers that focus on current and emerging therapies for osteoporosis. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership for more information about becoming a member. Zusammenfassung Our understanding of how the skeleton is remodeled and repaired has been enormously expanded in the past decade. Using advanced molecular technologies we are gaining a better understanding of both the precise pathways through which osteoblasts lay down new bone and how osteoclasts remove old bone. Inhaltsverzeichnis Part I: Skeletal Development:. 1. PTHrP and Skeletal Development: Henry Kronenberg. 2. Regulating Bone Growth with BMPs: Phoebe Leboy. 3. BMP and BMP Inhibitors in Bone: Vicki Rosen. 4. BMP Signaling and Skeletalogensis: Xu Cao. 5. Function of BMP and BMP Antagonist in Adult Bone: Etsuko Abe. 6. Dysregulation of the BMP4 Signaling Pathway in Fibrodysplasia Ossificans Progressiva: Frederick Kaplan. 7. Hypoxia, HIF-1¿Ñ and VHL in Chondrogenesis: Ernestina Schipani. 8. Cellular and Molecular Mechanisms of Synovial Joint and Articular Cartilage Formation: Maurizio Pacifici. 9. Multiple Roles of Hoxc8 in Skeletal Development: Aster Juan et al. Part II: Skeletal Remodeling:. 10. Osteoclasts and Integrins: Steven Teitelbaum. 11. Regulation of Osteoclast Differentiation: David Roodman. 12. Signaling in Osteoclast and their Precursors: Patrick Ross. 13. Canonical Wnt Signaling in Osteoblasts is Required for Osteoclast Differentiation: Gerard Karsenty. 14. Inhibition of ATF4 Transcriptional Activity by TIAT/¿×-Taxilin Modulates Bone Mass: Rene St. Arnaud. 15. Paget's Disease of Bone and Genetic Disorders of RANK/OPG/RANK/NF-¿ÛB signaling: Michael Whyte. 16. The Regulation of Cathepsin K Gene Expression: Bruce Troen. 17. Direct and Indirect Estrogen Actions on Osteoblasts and Osteoclasts: Alberta Zallone. 18. Molecular Mechanism of the Life and Death of the Osteoclast: Sakae Tanaka. 19. Understanding Parathyroid Hormone Action: Nicola Partridge. 20. New Insights Into the Mechanisms Involved in The Pleiotropic Actions of 1,25dihydroxyvitamin D3: Sylvia Christakos. 21. Mechanisms of Vitamin D Receptor A...
