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Zusatztext "...good reading for anyone entering into some aspect of cancer research! whether it is biological! mathematical! or computational..." (Biometrics! December 2006)"Overall ... an excellent and well-edited book that could be read from cover to cover or used as a reference." (British Journal of Healthcare Computing and Information Management! July 2006) Informationen zum Autor Dr Sylvia Nagl, Senior Lecturer, Department of Oncology, University College, London Klappentext The emerging field of cancer bioinformatics is facilitating an unprecedented synthesis of knowledge arising from the life and clinical sciences. The complexity of the questions being addressed requires experts from diverse backgrounds to engage in close and ongoing discourse and collaboration. They therefore need to be familiar with the research questions, terminology and methodology of the specialists in related subject areas.The primary aim of the book is to provide a comprehensive and up-to-date account of the enormous range of bioinformatics techniques now being developed for cancer research and therapy, from the laboratory to clinical trials. It will function as a guide to integrated data exploitation and synergistic knowledge discovery, and support the consolidation of the multidisciplinary research community involved.The book features a balanced range of topics, including both well-established techniques and emergent approaches in genomics, systems biology and e-science. Each chapter delivers an overview of the topic, combined with more detailed technical descriptions of key aspects of informatics, biology and clinical science. With contributions from clinical oncologists, research scientists, bioinformaticians and mathematical modellers, the book will facilitate scientific dialogue and collaboration across disciplinary boundaries. Finally, three chapters on the ethical and legal implications of cancer bioinformatics provide an expanded view of these groundbreaking developments and how they may impact on patients and other health care stakeholders.This multidisciplinary book will be of interest to a broad audience including clinical oncologists, basic researchers in both academia and industry, computer scientists/bioinformaticians, clinical trial managers, ethicists and ethics boards. Zusammenfassung "The development and application of bioinformatics tools to basic and translational cancer research is, in fact, a rapidly expanding field that deserves a timely review. Therefore, a publication of this type is needed. The editors have done an excellent job in recruiting well-established scientists to author the various chapters of the book. Inhaltsverzeichnis Preface. List of Contributors. SECTION I CANCER SYSTEMS. 1 A Path to Knowledge: from Data to Complex Systems Models of Cancer ( Sylvia Nagl ). 1.1 Conceptual foundations: biological complexity. 1.2 A taxonomy of cancer complexity. 1.3 Modelling and simulation of cancer systems. 1.4 Data standards and integration. 1.5 Concluding remarks. 2 Theory of Cancer Robustness ( Hiroaki Kitano ). 2.1 Robustness: the fundamental organizational principle of biological systems. 2.2 Underlying mechanisms for robustness. 2.3 Intrinsic features of robust systems: evolvability and trade-offs. 2.4 Cancer as a robust system. 2.5 Therapy strategies. 2.6 A proper index of treatment efficacy. 2.7 Computational tools. 2.8 Conclusion. 3 Developing an Integrated Informatics Platform for Cancer Research ( Richard Begent ). 3.1 Background. 3.2 The challenge. 3.3 The UK National Cancer Research Institute (NCRI) informatics platform. 3.4 Developing the informatics platform. 3.5 Benefits of the platform. 3.6 Conclusions. SEC...
