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Zusatztext This book! edited by Perry G. Wang! provides excellent up-to-date reviews on the newest developments of high-throughput analysis in drug discovery and development . . . has a good balance of both theoretical and practical information that should appeal to a broad base of readers . . . remains as a quick and valuable resource for the readers! ranging from professionals to academics! to gain knowledge about the most recent developments of high-throughput analysis in the pharmaceutical industry.- Keyang Xu! Genentech! Inc.! 2009? an appropriate and timely contribution to the scientific literature. ? offers valuable details and insights into each research area. ? very helpful to both newcomers to the field! as well as industry veterans.-Dr. James N. Kyranos! FORMA Therapeutics (US)! in ChemMedChem 2009! vol. 4 Informationen zum Autor Perry G. Wang Klappentext The introduction of combinatorial chemistry technology has increased the amount of compounds generated in a year from 50 to 2000. Conventional analytical approaches simply cannot keep up. These circumstances have caused drug discovery to take on the shape of a bottleneck! like traffic through a toll booth. In order to break the bottleneck! a corresponding revolutionary improvement to the conventional methodology must happen. Zusammenfassung The introduction of combinatorial chemistry technology has increased the amount of compounds generated in a year from 50 to 2000. Conventional analytical approaches simply cannot keep up. These circumstances have caused drug discovery to take on the shape of a bottleneck, like traffic through a toll booth. Inhaltsverzeichnis High-Throughput Sample Preparation Techniques and Their Application to Bioanalytical Protocols and Purification of Combinatorial Libraries. On-line Sample Extraction Coupled with Muliplexing Strategy to Improve Throughput. Optimizing LC/MS Equipment to Increase Throughput in Pharmaceutical Analysis. Throughput Improvement of Bioanalytical LC/MS/MS by Sharing Detector between HPLC Systems. High-Throughput Strategies for Metabolite Identification in Drug Discovery. Utilizing Microparallel Liquid Chromatography for High-Throughput Analyses in the Pharmaceutical Industry. Strategies and Techniques for Higher Throughput ADME/PK Assays. High-Throughput Analysis in Drug Metabolism During Early Drug Discovery. High-Throughput Analysis in Support of Process Chemistry and Formulation Research and Development in the Pharmaceutical Industry. Online Solid Phase Extraction LC/MS/MS for High-Throughput Bioanalytical Analysis. Applications of High-Throughput Analysis in Therapeutic Drug Monitoring. High-Throughput Quantitative Pharmaceutical Analysis in Drug Metabolism and Pharmacokinetics Using Liquid Chromatography–Mass Spectrometry. Designing High-Throughput HPLC Assays for Small and Biological Molecules. Advances in Capillary and Nano HPLC Technology for Drug Discovery and Development. High-Throughput Analysis of Complex Protein Mixtures by Mass Spectrometry. Index ...
