Read more
Zusatztext "...unique compendium of synthetic organic chemistry viewed through the eyes of an experienced chemist...simply no other publication like it..." (Synthesis! May 2007) Informationen zum Autor Someswara Rao is the author of The Chemistry of Process Development in Fine Chemical and Pharmaceutical Industry, 2nd Edition, published by Wiley. Klappentext This book brings together the chemical strategies used in the optimisation of organic reactions and processes, and highlights the practical and technological options available. This book offers:* an encyclopedic treatment of organic chemistry from an industrial, process research and development, and manufacturing point of view* plenty of examples to illustrate the scope and limitation of the strategies* a comprehensive index organised by topic, reaction type, and reagent* an extensive literature survey.This is an essential and comprehensive guide for experienced practitioners of chemical process research and development, fresh recruits to chemical industry R&D divisions, and academics who are interested in interacting with the chemical industry, optimising their synthetic strategies, and enriching the field of atom economy. Zusammenfassung The Chemistry of Process Development in Fine Chemical and Pharmaceutical Industry, Second Edition brings together various chemical strategies used in the optimization of organic reactions and processes, and highlights the practical and technological options available. Inhaltsverzeichnis Preface. Acknowledgements. Abbreviations. 1. The Nature of Process Development. 1.1 Introduction. 1.2 Desirable Goals of Process Development. 1.3 Evolution of an R & D Process into a Process Technology. 1.4 Scope and Limitations of Process Development. 1.5 The Role of Chemical Engineers. 1.6 Exploratory (Investigative) Approach to Optimization. 1.7 Statistical Approaches and Automated Works Stations. 1.8 Scale-up Considerations. 1.9 Process Development in Relation to Plant Equipment. 2. Survey of Some Organic Reactions in Relation to Process Development. 2.1 Introduction. 2.2 Preparation of Acid Chlorides from Carboxylic Acids. 2.3 Friedel-Crafts Acylations Acylations. 2.4 Grignard Reagents. 2.5 The Wittig Reaction. 2.6 Ozonolysis. 2.7 The Mitsunobu Reaction. 2.8 Photochemistry in Process Industry. 2.9 Very Low Temperature (Cryogenic) Chemistry (-70° to -100°). 2.10 Reactions Under Very High Pressures. 3. Chiral Technology. 3.1 Introduction. 3.2 Nature of Chirality. 3.3 Basic Assumptions of Chiral Technology. 3.4 Factors Responsible for the Rapid Growth of Chiral Technology. 3.5 Techniques for Obtaining Single Enantiomers. 3.6 The Chiral Pool. 3.7 Biotechnology. 3.8 Racemate Resolution Strategies. 3.9 Simplified Methodologies for Optical Resolution. 3.9 A Other Strategies for Racemati Resolution.130- 3.9 B Asymmetric Synthesis. 4. Strategies for Simplification of Organic Reactions and Processes. 4.1 Introduction. 4.2 Reaction Simplification Through in situ Generation of components. 4.3 Process Simplification. 5. Reagent Modification and Rate and Order of Addition of Reagents. 5.1 Introduction. 5.2 Supported Regents. 5.3 Complex formation to Modify Reagent Reactivity. 5.4 Effect of Aging of Reagents on Reactivity. 5.5 Rate of Addition of Reagents. 5.6 Order of Addition of Reagents. 6. Additives for Reagents-Fine Tuning of Organic Reactions. 6.1 Introduction. 6.2 Water as an Additive. 6.3 Covalent Organic Compounds as Additives. 6.4 Ionic Organic Compounds as Additives. 6.5 Met...
