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Klappentext Providing a state-of-the-art review of current research, this thoroughly updated and revised edition explains the history of the disease and examines how scientists, clinicians, and public health workers have responded to the challenges presented by HIV/AIDS in the 25 years since its recognition. Zusammenfassung The new edition provides a state-of-the-art review of the current research! explains the history of the disease! and examines how scientists! clinicians! and public health workers have responded to the challenge presented by HIV/AIDS in the 25 years since its recognition. Inhaltsverzeichnis Table of Contents 1. Discovery! Structure! and Origin of HIV 2. Features of HIV Transmission 3. Steps Involved in HIV: Cell Interaction and Virus Entry 4. Acute HIV Infection and Cells Susceptible to HIV Infection 5. Intracellular Control of HIV Replication 6. Cytopathic Properties of HIV 7. Viral Proteins Determining Biologic Features of HIV 8. Effect of HIV on Various Tissues and Organ Systems in the Host 9. Innate Immune Responses in HIV Infection 10. Humoral Immune Responses to HIV Infection 11. T-Lymphocyte Immune Responses in HIV Infection 12. HIV Infection and Development of Cancer 13. Overall Features of HIV Pathogenesis: Prognosis for Long-Term Survival 14. Antiviral Therapies 15. Vaccine Development Appendix I. 1993 Revised Classification System for HIV Infection and Expanded AIDS Surveillance Case Definition for Adolescents and Adults Appendix II. Clinical Categories Appendix III. Conditions Included in the 1993 AIDS Surveillance Case Definition Appendix IV. Other Definitions in HIV Infection: CD4+ T-Lymphocyte Categories