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Zusatztext "Miller's knowledge of the anatomy of neurological disorders is impressive. Only a person with a lifetime of experience in basal ganglia research could pull together such a wide range of information into a coherent model. We can all be grateful for the work of researchers like Robert Miller who have persevered for so many years in this area and are giving us all a coherent model of basal ganglia function." - James J. Jakubow in PsycCRITIQUES! Volume 54! No. 35! 2008 Informationen zum Autor Robert Miller Klappentext Although there is a wealth of information available on basal ganglia! this research field remains controversial in part due to the diverse number of disciplines involved. A Theory of the Basal Ganglia and their Disorders attempts to provide a clear! coherent view of basal ganglia that integrates evidence from the basic neurosciences! neurology! and psychiatry. Part I of the text develops a conceptual theory based on the normal function of basal ganglia. Part II of the book details the mechanisms that relate basic pathology to the manifestation of symptoms for related disorders! including Huntington's disease! Parkinson's disease! dopamine-related psychosis! and other psychotic disorders. Zusammenfassung Presents a view of basal ganglia. This book develops a conceptual theory based on the normal function of basal ganglia. It details the mechanisms that relate basic pathology to the manifestation of symptoms for related disorders, including Huntington's disease, Parkinson's disease, dopamine-related psychosis, and other psychotic disorders. Inhaltsverzeichnis THE FRAMEWORK FOR NORMAL BASAL GANGLIONIC FUNCTIONIntroduction: Background to the Dynamics of the Basal GangliaThe Cortico-Thalamo-Hippocampal Excitatory Network: Substrate for Cell Assemblies and Associative Operations Definition of Executive Functions The "Motor Thalamus": Target of Executive Decisions?The Striatum: Functional Significance and "Direct" Connectivity to Output Nuclei of the Basal GangliaThe Striatum: Detector and Encoder of Motivationally Significant Outcomes of Behavior and Deployer of Motivationally Favorable Behaviors Functional Subdivisions within Each Component of the Basal Ganglia The "Credit Assignment Problem" Morphological Evidence about the Fine Distribution of Connections in the Basal Ganglia Cybernetic Interpretations Derived from Quantitative Synaptology Collateral Inhibition in the Striatum The "Indirect" Pathways from Striatum to Basal Ganglia Output Nuclei! and Their Relation to the "Direct" Pathway Overall Patterns of Connectivity Segregation versus Overlap of "Direct" and "Indirect" Pathways from Striatum to Thalamus The "Credit Assignment Problem" in the Indirect Pathway Evidence on the Relative Role of "Direct" and "Indirect" Pathways Theories of Basal Ganglionic Function Early Theories Synopsis of Key Issues The "Scaling of Movement" Hypothesis The "Focused Selection" Hypothesis A More Complete Version of the "Focused Selection" Theory! Including Predictions Comparison with an Earlier Theory of the Basal Ganglia: Significance of Cell Assemblies Dynamics of Neural Activity in Structures of the Basal Ganglia and the Nature of the Neural Code in These Structures Synopsis of Part I and Predictions Derived from It INTERPRETATION OF SYMPTOMS OF DISEASES OF THE BASAL GANGLIAIntroduction General Comments Neuropathology and Pathophysiology of Disorders of the Basal Ganglia Huntington's Disease Parkinson's Disease and Parkinsonian Syndromes Introduction The "Goad and the Halter" in Parkinson's Disease Coactivation of Striatal Neurons and Cognitive Problems Associated with Parkinsonian Syndromes Inflexibility of Adjustments of Posture and Gait in Parkinson's DiseaseThe Role of the Subthalamus in Production of Parkinsonian Symptoms Burst Firing in Components of the Basal Ganglia and Parkinsonian Tremor Direct Connections from Basal Ganglia to Brain Stem! and...
