Signaling By Toll-Like Receptors

Informationen zum Autor Gregory W. Konat Klappentext The discovery of toll-like receptors (TLRs) spurred the field of innate immunity into a renaissance after many years of neglect. Since then! TLR research has grown at an exponential rate. Taking an integrated methodological approach! Signaling by Toll-Like Receptors offers a comprehensive review of important techniques in molecular biology! cell biology! biochemistry! genetics! and immunology and their critical application to the study of toll-like receptor structure! biological function! and the intracellular signaling triggered by these receptors. Zusammenfassung Presents a review of important techniques in molecular biology, cell biology, biochemistry, genetics, and immunology and their critical application to the study of toll-like receptor structure, biological function, and the intracellular signaling triggered by these receptors, as well as the promise for uncovering effective pharmaceutical targets. Inhaltsverzeichnis Assessing the Response of Cells to TLR Stimulation. TLR Ligands in Experimental Settings: Their Purity and Specificity. Analysis of TLR Expression, Regulation, and Signaling. Intracellular Trafficking of Toll-Like Receptors. The Role of Small RhoGTPases in TLR Signaling. Use of Engineered ß-Lactamase Fragment Complementation to Detect the Associations of Toll-Like Receptors and Signaling Adaptors. Use of Toll-Like Receptor Chimeras to Dissect Mechanisms of Receptor Localization and Signaling. Engagement of Toll-Like Receptors Modulates Chemokine Receptor Signaling. Role of Toll-Like Receptor Signaling in Central Nervous System Infections. The Influence of Injury on Toll-Like Receptor Responses. Index.

Product details

• Authors: Gregory W. Konat, Gregory W. (West Virginia University Konat
• Assisted by: Gregory W. Konat (Editor), Gregory W. (West Virginia University Konat (Editor), Konat Gregory W. (Editor)
• Publisher: Taylor & Francis Ltd.
• Languages: English
• Product format: Hardback
• Released: 20.06.2008
• EAN: 9781420043181
• ISBN: 978-1-4200-4318-1
• No. of pages: 220
• Series: Methods in Signal Transduction Series; Methods in Signal Transduction Series
• Subjects: Natural sciences, medicine, IT, technology > Biology > Genetics, genetic engineering; Immunology, SCIENCE / Life Sciences / General, MEDICAL / Immunology, SCIENCE / Life Sciences / Cell Biology, SCIENCE / Research & Methodology, Cellular biology (cytology)